货号：MABT78

品牌：Merck Millipore

规格：100Ug

目录价：￥4592.00

市场价格：￥3903.20

会员价格：￥3673.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-mouse CD44 (H-CAM) Antibody, clone KM201 | MABT78 View All» Replaces: CBL1308 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: The antibody recognizes CD44 near the hyaluronate binding domain. View All» Molecular Weight: 86 kDa calculated View All» Epitope: Near the hyaluronate binding domain View All» Immunogen: Mouse bone marrow-derived stromal cells View All» Clone: KM201 View All» Isotype: IgG1κ View All» Background Information: CD44, also known as H-CAM is a distinct adhesion molecule that, with its 13 known isoforms, comprises a family of transmembrane glycoproteins involved in a wide variety of significant biological processes. Members belonging to this family are involved in apoptosis, migration, metastasis, tumor progression, lymphocyte homing, and the attachment of hematopoietic cells to stromal cells. CD44 is the primary cell surface receptor for hyaluronic acid (HA), and is also a notable target for WNT signaling within the intestinal mucosa. Recent studies have used CD44 marker as a means to isolate different cancer stem cells (CSC) such as; colorectal CSC, pancreatic CSC, and prostate CSC. View All» Species Reactivity: Mouse View All» Species Reactivity Note: Demonstrated to react with mouse. View All» Control: Mouse bone marrow cells View All» Quality Assurance: Evaluated by Flow Cytometry in mouse bone marrow cells.Flow Cytometry Analysis: 0.1 µg of this antibody detected CD44 in mouse bone marrow cells. View All» Purification Method: Protein G View All» Presentation: Purified rat monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine, pH 7.4, 150 mM NaCl, with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P15379 View All» Entrez Gene Number: NP_001034240 View All» Gene Symbol:

• CD44

• CD44R

• CDW44

• CDw44

• CSPG8

• ECMR-III

• Epican

• HCELL

• HUTCH-I

• IN

• LHR

• MC56

• MDU2

• MDU3

• MIC4

• MUTCH-I

• PGP-1

• PGP-I

• Pgp1
  View All» Alternate Names:
  • CD44 antigen (homing function and Indian blood group system)

  • CDw44 antigen

  • HCAM

  • H-CAM

  • HUTCH-1

  • Phagocytic glycoprotein I

  • Extracellular matrix receptor III

  • GP90 lymphocyte homing/adhesion receptor

  • Heparan sulfate proteoglycan

  • Hermes antigen

  • Hyaluronate receptor

  • Epican

  • antigen gp90 homing receptor

  • chondroitin sulfate proteoglycan 8

  • hematopoietic cell E- and L-selectin ligand
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Flow Cytometry View All» UniProt Summary: FUNCTION: Main cell surface receptor for hyaluronate. Adhesion to mucosal high endothelial venule and to types I and VI collagen. Probably involved in matrix adhesion, lymphocyte activation and lymph node homing.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. PTM: N-glycosylated By similarity.O-glycosylated; contains chondroitin sulfate glycans which can be more or less sulfated (By similarity).Phosphorylated; activation of PKC results in the dephosphorylation of Ser-742 (constitutive phosphorylation site), and the phosphorylation of Ser-708 (By similarity). POLYMORPHISM: Two allelic forms of this glycoprotein, PGP-1.1 and PGP-1.2, have been reported. The expressed product is PGP-1.1 (Ly-24.1).SEQUENCE SIMILARITIES: Contains 1 Link domain. View All» Product Name: Anti-mouse CD44 (H-CAM), clone KM201 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rat View All»
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