货号：MABT84

品牌：Merck Millipore

规格：1EA

目录价：￥4986.69

市场价格：￥4238.69

会员价格：￥3989.35

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Aggrecan Antibody, clone 1-C-6 | MABT84 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: Various View All» Immunogen: Reduced and alkylated Aggrecan isolated from Swarm Rat Chondrosarcoma View All» Clone: 1-C-6 View All» Isotype: IgG1κ View All» Background Information: Aggregating chondroitin sulfate proteoglycan or aggrecan, is one of the most studied proteoglycans. Many individual monomers of aggrecan bind to hyaluronic acid to form an aggregate, the monomer is known as aggrecan. The aggregates are comprised of up to 100 monomers attached to a single chain of hyaluronic acid. The high content of negatively charged polysaccharide chains contributes to the osmotic swelling of cartilage and in combination with intact collagen fibers results in articular cartilage resistance to compressive forces and high tensile strength. Aggrecan is abundant in articular cartilage and compromises 10% of its dry weight. View All» Species Reactivity:

• Rat

• Mouse

• Bovine
  View All» Species Reactivity Note: Demonstrated to react with Rat, Mouse, and Bovine. View All» Application Notes: Western Blot Analysis: 1 µg/mL from a representative lot detected Aggrecan on 10 µg of A1D4 protein fraction from Bovine tissue. View All» Control: Normal mouse cartilage and normal rat cartilage tissues View All» Quality Assurance: Evaluated by Immunohistochemistry in normal mouse cartilage and normal rat cartilage tissues.Immunohistochemistry Analysis: A 1:1,000 dilution of this antibody detected Aggrecan in normal mouse cartilage and normal rat cartilage tissues. View All» Purification Method: Protein G purified View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P07897 View All» Entrez Gene Number: NP_071526 View All» Gene Symbol:
  • Acan

  • Agc

  • Agc1
    View All» Alternate Names:
    • Aggrecan core protein

    • Cartilage-specific proteoglycan core protein

    • CSPCP
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunohistochemistry

      • Western Blotting
        View All» Entrez Gene Summary: An extracellular matrix proteoglycan; cleaved by ADAMTS1 [RGD, Feb 2006]. View All» UniProt Summary: FUNCTION: This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.SUBUNIT STRUCTURE: Interacts with FBLN1 and COMP (By similarity).SUBCELLULAR LOCATION: Secreted › extracellular space › extracellular matrix (By similarity). DOMAIN: Two globular domains, G1 and G2, comprise the N-terminus of the proteoglycan, while another globular region, G3, makes up the C-terminus. G1 contains Link domains and thus consists of three disulfide-bonded loop structures designated as the A, B, B' motifs. G2 is similar to G1. The keratan sulfate (KS) and the chondroitin sulfate (CS) attachment domains lie between G2 and G3.PTM: Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides.SEQUENCE SIMILARITIES: Belongs to the aggrecan/versican proteoglycan family.Contains 1 C-type lectin domain.Contains 1 Ig-like V-type (immunoglobulin-like) domain.Contains 4 Link domains.Contains 1 Sushi (CCP/SCR) domain. View All» Product Name: Anti-Aggrecan, clone 1-C-6 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Target / Localization: Initiation of chondrogenesis View All» Format: Purified View All» Host: Mouse View All»
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