货号：MABT86

品牌：Merck Millipore

规格：EA

目录价：￥3696.00

市场价格：￥3141.60

会员价格：￥2956.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Keratocan Antibody, clone KER-1 | MABT86 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~40 kDa observed View All» Immunogen: Keratocan from partially purified keritinase II-treated bovine corneal extract. View All» Clone: KER-1 View All» Isotype: IgMκ View All» Background Information: Keratocan is an extracellular matrix protein that belongs to the small leucine-rich proteoglycan (SLRP) family that also includes lumican, biglycan, decorin, mimecan, and fibromodulin. Members of this family are known to regulate cellular processes, such as proliferation and modulation of osteoprogenitor lineage differentiation. Keratocan is differentially expressed by osteoblasts and shows little or no expression in osteocytes. Lumican and Keratocan are the major keratan sulfate (KS) proteoglycans in corneal stroma. Both proteins are critical for normal cornea morphogenesis during embryonic development and maintenance of corneal topography in adults. It is shown that homozygous Keratocan knockout mice display abnormal corneas, significantly decreased rates of bone formation and mineral apposition, larger fibril diameters, and disorganized fibril spacing. Keratocan mutation leads to cornea plana in humans, which is often associated with glaucoma. Experimental evidence indicates that lumican may have additional biological functions, such as modulation of cell migration and epithelium-mesenchyme transition in wound healing and tumorgenesis, aside from regulating collagen fibrillogenesis. View All» Species Reactivity:

• Rat

• Bovine
  View All» Species Reactivity Note: Demonstrated to react with Rat. Predicted to react with Bovine based on immunogen design. View All» Application Notes: Immunohistochemistry Analysis: A previous lot from an independent laboratory detected Keratocan in the anterior stroma of developing chick corneas. (Gealy, E.C., et al. (2007). Histochem Cell Biol. 128(6):551-555.) View All» Control: Rat eye tissue lysate. View All» Quality Assurance: Evaluated by Western Blot in rat eye tissue lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected Keratocan in 10 µg of rat eye tissue lysate. View All» Purification Method: Purified by ion-exchange chromatography View All» Presentation: Purified mouse monocolonal IgMk in buffer containing PBS with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O62702 View All» Entrez Gene Number: NP_776335 View All» Gene Symbol: KERA View All» Alternate Names:
  • KTN

  • Corneal keratan sulfate proteoglycan 37A core protein

  • Keratan sulfate proteoglycan keratocan

  • KSPG keratocan
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry
      View All» UniProt Summary: FUNCTION: May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix (By similarity).SUBCELLULAR LOCATION: Secreted > extracellular space > extracellular matrix.TISSUE SPECIFICITY: Abundant in cornea and sclera but also found in other tissues. View All» Product Name: Anti-Keratocan, clone KER-1 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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