货号：MBN-41K-1OPG

品牌：Merck Millipore

规格：EA

目录价：￥6201.00

市场价格：￥5270.85

会员价格：￥4960.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: MILLIPLEX MAP Mouse OPG - Single Plex View All» Trade Name: MILLIPLEX View All» Qty/Pk: 96-well plate View All» Background Information: This single plex assay kit is to be used for the quantitative measurement of mouse OPG in cell/tissue culture supernatant and mouse serum/plasma samples. Osteoprotegerin (OPG, also known as OCIF or osteocalstogenesis inhibitory factor) is a soluble member of t View All» Key Applications: Multiplexing View All» Application Notes: 25 µL or less sample volume, Overnight assay View All» Species Reactivity: Mouse View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Entrez Gene Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. View All» UniProt Summary: FUNCTION: SwissProt: O00300 # Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis.SIZE: 401 amino acids; 46040 Da SUBUNIT: Homodimer.SUBCELLULAR LOCATION: Secreted.TISSUE SPECIFICITY: Highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow. Detected at very low levels in brain, placenta and skeletal muscle. Highly expressed in fetal kidney, liver and lung.PTM: N-glycosylated. Contains sialic acid residues. & The N-terminus is blocked.DISEASE: "SwissProt: O00300 # Defects in TNFRSF11B are the cause of juvenile Paget disease (JPD) [MIM:239000]; also called hyperostosis corticalis deformans juvenilis or hereditary hyperphosphatasia or chronic congenital idiopathic hyperphosphatasia. JPD is a rare autosomal recessive osteopathy that presents in infancy or early childhood. The disorder is characterized by rapidly remodeling woven bone, osteopenia, debilitating fractures, and deformities due to a markedly accelerated rate of bone remodeling throughout the skeleton. Approximately 40 cases of JPD have been reported worldwide. Unless it is treated with drugs that block osteoclast- mediated skeletal resorption, the disease can be fatal."SIMILARITY: SwissProt: O00300 ## Contains 2 death domains. & Contains 4 TNFR-Cys repeats. View All» Linearity of Dilution: 1.12 View All» Sensitivity: 2.3 pg/mL View All» Cross Reactivity: Mouse OPG assay shows reactivity with recombinant rat OPG. View All» Product Name: MILLIPLEX MAP Mouse OPG - Single Plex View All» Standard Curve Range: 10–40,000 pg/mL View All» Analytes Available: Osteoprotegerin View All» Configuration: Single Plex View All» UniProt Number:

• O00300

• O08712
  View All» Panel Type: Non-Magnetic Bone View All» Precision, %:
  • Inter-assay: 6.0

  • Intra-assay: 3.1
    View All» Accuracy: 0.83 View All» Detection Methods:
    • Fluorescent

    • Luminex xMAP
      View All» Assay Panel: Everything you need in a single kit. View All»
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