货号：05-1576

品牌：Merck Millipore

规格：EA

目录价：￥3468.00

市场价格：￥2947.80

会员价格：￥2774.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-BOB-1 Antibody, clone 6E4 | 05-1576 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~ 32 kDa observed. Other sizes may be observed due to ubiquination. View All» Immunogen: GST-tagged recombinant protein corresponding to mouse BOB-1. View All» Clone: 6E4 View All» Isotype: IgG2aκ View All» Background Information: B-cell-specific coactivator OBF-1(BOB-1) is a transcriptional coactivator protein specific to B-cells. BOB-1 has been shown to interact with transcriptional factors OCT1 and OCT2, binding to their POU domain and mediating transcriptional activity of octamer motifs to varying degrees. Reportedly, BOB-1 is a required component of both the B-cell to antigen response and germinal center formation. The highest observed expression for BOB-1 is in plasma cells and B-cell germinal centers. Expression of BOB-1 has also been observed in B-cell tumors; however, it is considered to be variable. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with human and mouse. View All» Application Notes: Immunohistochemistry:Using a representative lot of this antibody, an idependent laboratory reported detection of BOB-1 in spleen and lymph node of immunized mice. View All» Control: Daudi cell lysate View All» Quality Assurance: Evaluated by Western Blot in Daudi cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected BOB-1 on 10 µg of Daudi cell lysate. View All» Purification Method: Protein G View All» Presentation: Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q64693 View All» Entrez Gene Number: NP_035266 View All» Gene Symbol:
  • BOB-1

  • BOB1

  • POU

  • OBF1

  • OBF-1

  • OCAB

  • OCA-B

  • POU2AF1
    View All» Alternate Names:
    • POU class 2 associating factor 1

    • POU domain class 2, associating factor 1

    • OCT-binding factor 1

    • POU domain, class 2, associating factor 1

    • B-cell-specific coactivator OBF-1

    • POU domain class 2-associating factor 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry
        View All» UniProt Summary: FUNCTION: Transcriptional coactivator that specifically associates with either OCT1 or OCT2. Its boost the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centres.SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICTY: B-cell specific.PTM: Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation (By similarity).SEQUENCE SIMILARITIES: Belongs to the POU2AF1 family. View All» Product Name: Anti-BOB-1, clone 6E4 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rat View All»
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