货号：05-1583

品牌：Merck Millipore

规格：100Ug

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PRL-2 Antibody, clone 42 | 05-1583 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes PRL-2. View All» Molecular Weight: ~ 19 kDa View All» Epitope: Unknown View All» Immunogen: GST-tagged recombinant protein corresponding to mouse PRL-2. View All» Clone: 42 View All» Isotype: IgG2bκ View All» Background Information: PRL-2 is one of three members (PRL-1, PRL-2, and PRL-3) that is part of a unique protein-tyrosine phosphatase ((PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP is known to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferres a transformed phenotype and can result in a tumor growth in nude mice, suggesting a role in tumorigenesis. Alternatively spliced transcript variants that encode two distinct isoforms have been described View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with mouse based on 100% sequence homology. View All» Application Notes: Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in IH. Immunoprecipitation Analysis: A representative lot was used by an independent laboratory in IP. View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysate.Western Blot Analysis: 0.5 µg/ml of this antibody detected PRL-2 on 10 µg of HeLa cell lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: O70274 View All» Entrez Gene Number: NP_001158217.1 View All» Gene Symbol:
  • ptp4a2

  • HH13

  • HH7-2

  • HU-PP-1

  • OV-1

  • PRL-2

  • PRL2

  • PTP(CAAXII)

  • PTP4A

  • PTPCAAX2

  • ptp-IV1a

  • ptp-IV1b
    View All» Alternate Names:
    • Protein-tyrosine phosphatase 4a2

    • Protein-tyrosine phosphatase of regenerating liver 2

    • phosphatase of regenerating liver 2

    • protein tyrosine phosphatase IVA

    • protein tyrosine phosphatase IVA2

    • protein tyrosine phosphatase type IVA, member 2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry

      • Immunoprecipitation
        View All» UniProt Summary: FUNCTION: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Inhibits geranylgeranyltransferase type II activity by blocking the association between RABGGTA and RABGGTB By similarity.CATALYTIC ACTIVITY: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.ENZYME REGULATION: Inhibited by sodium orthovanadate and pentamidine By similarity.SUBUNIT STRUCTURE: In contrast to PTP4A1 and PTP4A3, does not interact with tubulin. Interacts with RABGGTB By similarity.SUBCELLULAR LOCATION: Cell membrane. Early endosome. Cytoplasm TISSUE SPECIFICTY: Expressed in skeletal muscle, and at lower levels in liver, lung, heart, kidney, brain, testis and spleen. Ref.1PTM: Farnesylated. Farnesylation is required for membrane targeting and for interaction with RABGGTB By similarity.SEQUENCE SIMILARITIES: Belongs to the protein-tyrosine phosphatase family.Contains 1 tyrosine-protein phosphatase domain. View All» Product Name: Anti-PRL-2, clone 42 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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