货号：05-166

品牌：Merck Millipore

规格：500Ug

目录价：￥5974.00

市场价格：￥5077.90

会员价格：￥4779.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-IGF-II Antibody, clone S1F2 | 05-166 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: This antibody detects IGF-II. View All» Molecular Weight: ~7 kDa View All» Immunogen: Partially purified rat IGF-II. Clone S1F2 View All» Clone: S1F2 View All» Isotype: IgG1 View All» Background Information: Human Insulin-like Growth Factor II (IGFII) contains 67 amino acids and shares similar structural features with IGFI, including a 62% sequence homology. In human plasma, IGFI and IGFII are associated with IGF-binding proteins that transport the polypeptides and partially regulate their actions in vivo. In addition to the insulin receptor, IGFII binds to two forms of IGF receptors, both of which are widely distributed in different tissues and cultured cells. IGFII is mitogenic for a variety of cultured cells, including mouse 3T3 cells,12 normal rat kidney cells, human or chicken fibroblasts and MCF-7 human breast carcinoma cells. View All» Species Reactivity:

• Human

• Rat
  View All» Species Reactivity Note: Recognizes rat and human IGF-II. Less than 10% cross-reactivity to human IGF-I (Tanaka, H, 1989; Suzuki, T, 1989). View All» Application Notes: Neutralization: 10 μg/mL of a previous lot inhibited the stimulatory effects of IGF-II (10 ng/mL) on DNA synthesis in chicken embryo fibroblasts. Cell viability was assessed using an ATP endpoint assay (ATPLiteÔ-M, Packard Instruments). Previous lots of antibody were tested to inhibit IGF-II-dependent incorporation of [3H]-thymidine View All» Control: Human head and neck tumours, angioma tissues View All» Quality Assurance: Evaluated by Western Blotting on HeLa acid extracted nuclear preps (positive) and recombinant Histone H3 (negative).Western Blotting Analysis: 1:5,000 – 1:10,000 dilution of this antibody was used to detect trimethylated-Histone H3 (Lys4) in HeLa nuclear acid extracts. View All» Purification Method: Ammonium sulfate precipitation and DEAE-cellulose chromatography View All» Presentation: Purified mouse monoclonal IgG1 in buffer containing PBS, pH 7.4., purified by ammonium sulfate precipitation and DEAE-cellulose chromatography. Frozen solution. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt. View All» UniProt Number: P01344 View All» Entrez Gene Number: NM_000612 View All» Gene Symbol:
  • IGF2

  • FLJ22066

  • FLJ44734

  • pp9974

  • IGF-II

  • INSIGF

  • C11orf43
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • ELISA

    • Immunoprecipitation

    • Immunocytochemistry

    • Neutralizing

    • Western Blotting
      View All» Entrez Gene Summary: This gene encodes a member of the insulin family of polypeptide growth factors that is involved in development and growth. It is an imprinted gene and is expressed only from the paternally inherited allele. It is a candidate gene for eating disorders. There is a read-through, INS-IGF2, which aligns to this gene at the 3' region and to the upstream INS gene at the 5' region. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. View All» UniProt Summary: FUNCTION: SwissProt: P01344 # The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.SIZE: 180 amino acids; 20140 Da SUBCELLULAR LOCATION: Secreted.SIMILARITY: SwissProt: P01344 ## Belongs to the insulin family. View All» Brand Family: Upstate View All» Product Name: Anti-IGF-II Antibody, clone S1F2 | 05-166 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 500 μg View All» Format: Purified View All» Host: Mouse View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://www.16ao.com/thread-133677.htm
      © Merck Millipore代理05-166 Anti-IGF-II Antibody, clone S1F2;store at -20℃，产品报价联系微信jinshanbio