货号：05-175

品牌：Merck Millipore

规格：250Ug

目录价：￥5207.00

市场价格：￥4425.95

会员价格：￥4165.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Myb Antibody, clone 1-1 | 05-175 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: This antibody recognizes Myb, Mr 80 kDa, containing C-terminal amino acids from 401-636 (Salomoni, P., 1997). View All» Molecular Weight: 80 kDa View All» Immunogen: Recombinant murine Myb purified by SDS-PAGE (Nicot, C., 2001) Clone 1-1. View All» Clone: 1-1 View All» Isotype: IgG2aκ View All» Background Information: Myb is a transcriptional activator. It is a DNA-binding protein that specifically recognizes the sequence 5'-YAAC[GT]G-3'. Myb plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Human, Mouse View All» Application Notes: Immunoprecipitation: 4 μg of previous lot immunoprecipitated Myb from Jurkat cell lysate.Immunohistochemistry: View All» Control: Jurkat cell lysate.Included Positive Antigen Control: Catalog # 12-303, Jurkat cell lysate. Add 2.5 μL of 2-mercaptoethanol/100 μL of lysate and boil for 5 minutes to reduce the preparation. Load 20 μg of reduced lysate per lane for minigels. View All» Quality Assurance: Routinely evaluated on RIPA lysate from Jurkat cells.Western Blot Analysis: 0.5-2 μg/mL of this lot detected Myb in 20 μg of RIPA lysate from Jurkat cells. View All» Purification Method: Ammonium sulfate precipitation, gel filtration, and ion-exchange chromatography. View All» Presentation: Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-glycine, pH 7.4, 0.15 M NaCl and 0.05% sodium azide. Frozen solution. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: P10242 View All» Entrez Gene Number: NM_005375.2 View All» Gene Symbol:
  • MYB

  • C-myb

  • c-myb13A_CDS

  • c-myb8B_CDS

  • c-myb_CDS

  • v-myb

  • c-myb14A_CDS

  • Cmyb

  • c-myb

  • efg

  • c-myb10A_CDS
    View All» Alternate Names:
    • Avian myeloblastosis viral (v-myb) oncogene homolog 2 c-myb protein (140 AA)

    • v-myb avian myeloblastosis viral oncogene homolog

    • v-myb avian myeloblastosis viral oncogene homolog

    • v-myb myeloblastosis viral oncogene homolog

    • v-myb myeloblastosis viral oncogene homolog (avian)
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunohistochemistry

      • Immunoprecipitation

      • Western Blotting
        View All» UniProt Summary: FUNCTION: SwissProt: P10242 # Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.SIZE: 640 amino acids; 72341 Da SUBUNIT: Binds MYBBP1A. Interacts with HIPK2 and NLK (By similarity).SUBCELLULAR LOCATION: Nucleus.DOMAIN: SwissProt: P10242 Comprised of 3 domains; an N-terminal DNA-binding domain, a centrally located transcriptional activation domain and a C- terminal domain involved in transcriptional repression.PTM: Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation (Probable). & Phosphorylated by NLK on multiple sites, which induces proteasomal degradation (By similarity).SIMILARITY: Contains 3 HTH myb-type DNA-binding domains. View All» Brand Family: Upstate View All» Product Name: Anti-Myb Antibody, clone 1-1 | 05-175 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 250 µg View All» Format: Purified View All» Host: Mouse View All»
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