货号：05-178

品牌：Merck Millipore

规格：

目录价：￥3639.00

市场价格：￥3093.15

会员价格：￥2911.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-RasGAP Antibody, clone B4F8 | 05-178 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: human GAP View All» Molecular Weight: 120 kDa View All» Immunogen: Recombinant full length human RasGAP expressed in Sf9 cells View All» Isotype: IgG View All» Species Reactivity:

• Bovine

• Human

• Hamster

• Mouse

• Rat
  View All» Quality Assurance: Immunoprecipitation: 2.5 μg of this antibody immunoprecipitated RasGAP from 500 μg of A431 cell lysate.Immunoblot Analysis: 0.5-2 μg/ml of this antibody detected RasGAP in 20 μg of A431 cell lysate.Immunocytochemistry: 10 μg/ml of this antibody detected RasGAP on A431 cells fixed with ethanol/acetic acid [50:50]. View All» Purification Method: Protein G chromatography View All» Presentation: 0.07 M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide and 30% glycerol. View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: P20936 View All» Entrez Gene Number:
  • NM_002890.1

  • NM_022650.1
    View All» Gene Symbol:
    • RASA1

    • CMAVM

    • CM-AVM

    • RASA

    • PKWS

    • GAP

    • p120GAP

    • RASGAP

    • RasGAP

    • DKFZp434N071
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunocytochemistry

      • Immunoprecipitation

      • Western Blotting
        View All» Entrez Gene Summary: The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. View All» UniProt Summary: FUNCTION: SwissProt: P20936 # Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21.SIZE: 1047 amino acids; 116403 Da SUBUNIT: Interacts with SQTSM1.SUBCELLULAR LOCATION: Cytoplasm.PTM: The N-terminus is blocked.DISEASE: SwissProt: P20936 # Mutations in the SH2 domain of RASA seem to be oncogenic and cause basal cell carcinomas. & Defects in RASA1 are the cause of capillary malformation- arteriovenous malformation (CMAVM) [MIM:608354]. CMAVM is a disorder characterized by atypical capillary malformations that are multiple, small, round to oval in shape and pinkish red in color. These capillary malformations are associated with either arteriovenous malformation, arteriovenous fistula, or Parkes Weber syndrome. & Defects in RASA1 are a cause of Parkes Weber syndrome (PKWS) [MIM:608355]. PKWS is a disorder characterized by a cutaneous flush with underlying multiple micro-arteriovenous fistulas, in association with soft tissue and skeletal hypertrophy of the affected limb.SIMILARITY: SwissProt: P20936 ## Contains 1 C2 domain. & Contains 1 PH domain. & Contains 1 Ras-GAP domain. & Contains 2 SH2 domains. & Contains 1 SH3 domain. View All» Brand Family: Upstate View All» Product Name: Anti-RasGAP Antibody, clone B4F8 | 05-178 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 200 µg View All» Format: Purified View All» Host: Mouse View All»
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