货号：05-354

品牌：Merck Millipore

规格：100Ug

目录价：￥6434.00

市场价格：￥5468.90

会员价格：￥5147.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Clusterin α chain (human) Antibody, clone 41D | 05-354 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: This antibody recognizes human clusterin α chain, Mr 40 kDa, and precursor protein. View All» Molecular Weight: 40 kDa View All» Immunogen: Native clusterin purified from human serum. Clone 41D. View All» Clone: 41D View All» Isotype: IgG1κ View All» Background Information: Clusterin is also known as apolipoprotein J, complement lysis inhibitor, gp80, glycoprotein III, SGP-2, SP 40-40, TRPM2 and T64. It is a ubiquitous multifunctional protein of 80kD comprising of two disulfide-linked subunits, alpha and beta, and capable of interacting with a broad range of molecules. It is implicated in numerous biological processes including sperm maturation, lipid transport, regulation of the complement cascade, membrane recycling, cell death, immune regulation, cell adhesion and morphological transformation. In pathological conditions, it is an amyloid associated protein co-localising with fibrillar deposits in systemic and localised amyloid disorders. In Alzheimer ’s disease, clusterin is present in amyloid plaques and cerebrovascular deposits. In breast cancers, clusterin expression was found to correlate with tumour size. Clusterin is also implicated with endometrial cancers, myocardial infarction, renal diseases and atherosclerosis. View All» Species Reactivity: Human View All» Species Reactivity Note: Human. View All» Application Notes: Immunohistochemistry: Previous lots of this antibody at 5 µg/mL detected clusterin in paraffin embedded human brain sections. View All» Control: HeLa cell lysate. View All» Quality Assurance: Routinely evaluated on RIPA lysates from HeLa cells or MCF-7 cell lysates.Western Blot Analysis: 0.5-2 µg/mL of a previous lot detected human clusterin α chain in RIPA lysates from HeLa cells; previous lots detected the protein in human serum and MCF-7 cell lysates View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-glycine, pH 7.4, 0.15 M NaCl, with 0.05% sodium azide. Frozen at -20°C. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: P10909 View All» Entrez Gene Number: NM_203339 View All» Gene Symbol:

• CLU

• SP-40

• MGC24903

• NA1/NA2

• SGP-2

• AAG4

• KUB1

• APOJ

• CLI

• TRPM-2

• TRPM2

• Apo-J

• SGP2
  View All» Alternate Names:
  • Apolipoprotein J

  • Complement cytolysis inhibitor

  • Complement-associated protein SP-40,40

  • Ku70-binding protein 1

  • Testosterone-repressed prostate message 2

  • aging-associated protein 4

  • clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J)

  • complement lysis inhibitor

  • complement-associated protein SP-40

  • sulfated glycoprotein 2
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunocytochemistry

    • Immunohistochemistry

    • Immunohistochemistry (Paraffin)

    • Western Blotting
      View All» UniProt Summary: FUNCTION: SwissProt: P10909 # Not yet clear. It is known to be expressed in a variety of tissues and it seems to be able to bind to cells, membranes and hydrophobic proteins. It has been associated with programmed cell death (apoptosis).SIZE: 449 amino acids; 52495 Da SUBUNIT: Antiparallel disulfide-linked heterodimer. Interacts with CLUAP1.SUBCELLULAR LOCATION: Secreted.SIMILARITY: SwissProt: P10909 ## Belongs to the clusterin family. View All» Brand Family: Upstate View All» Product Name: Anti-Clusterin α chain (human) Antibody, clone 41D | 05-354 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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