货号：05-369X-555

品牌：Merck Millipore

规格：25Ug

目录价：￥1347.00

市场价格：￥1144.95

会员价格：￥1077.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Na+/K+ ATPase α-1 Antibody, clone C464.6, Alexa Fluor® 555 | 05-369X-555 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Specific for the α-1 subunit isoform. View All» Molecular Weight: 113 kDa View All» Immunogen: Purified Na+/K+ ATPase isolated from membrane fractions of rabbit kidney outer medulla. View All» Clone: C464.6 View All» Isotype: IgG1 View All» Species Reactivity:

• Canine

• Human

• Mouse

• Monkey

• Pig

• Rat

• Rabbit

• Sheep

• Xenopus
  View All» Control: Included Negative Control: Catalog # 16-239, Alexa Fluor® 555-conjugated Normal Mouse IgG. View All» Quality Assurance: Immunoblot Analysis: 2µg/ml of this lot detected α-1 subunit in 40μg of rat brain microsomal preparation. Immunocytochemistry: 2µg/ml of this lot showed positive immunostaining for α-1 subunit in Colo 205 cells. Flow Cytometry: 0.2μg of this lot detected α-1 subunit in fixed NCI H292 cells (see data). View All» Purification Method: Protein G purfied View All» Presentation: 25µg Alexa Fluor® 555-conjugated protein G purified mouse IgG1κ in 100µl of PBS containing 1% BSA, 0.05% Tween®-20, 0.05% sodium azide. Liquid at 4°C. View All» Storage Conditions: Do Not Freeze. Do not store the material diluted. Stable for 1 year at 4°C from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing cap. View All» UniProt Number: P13637 View All» Entrez Gene Number: NM_152296.3 View All» Gene Symbol:
  • ATP1A3

  • MGC13276

  • RDP

  • IIIsubunit).

  • DYT12

  • +K

  • Na
    View All» Usage Statement:
    • Alexa Fluor® is a registered trademark of Molecular Probes, Inc.

    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      View All» Key Applications:
      • Flow Cytometry

      • Immunofluorescence

      • Western Blotting
        View All» Entrez Gene Summary: The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 3 subunit. View All» UniProt Summary: FUNCTION: SwissProt: P13637 # This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.SIZE: 1013 amino acids; 111749 Da SUBUNIT: Composed of three subunits: alpha (catalytic), beta and gamma.SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.DISEASE: SwissProt: P13637 # Defects in ATP1A3 are the cause of dystonia-12 (DYT12) [MIM:128235]; also known as rapid-onset dystonia parkinsonism (RDP). DYT12 is an autosomal dominant form of dystonia- parkinsonism characterized by an unusually rapid evolution of signs and symptoms. Affected persons develop dystonia and parkinsonism between 14 and 45 years of age. The sudden onset of symptoms over hours to a few weeks, often associated with physical or emotional stress, suggests a trigger initiating a nervous system insult resulting in permanent neurologic disability.SIMILARITY: SwissProt: P13637 ## Belongs to the cation transport ATPase (P-type) family. Type IIC subfamily. View All» Brand Family: Upstate View All» Product Name: Anti-Na+/K+ ATPase α-1 Antibody, clone C464.6, Alexa Fluor® 555 | 05-369X-555 View All» Concentration: 0.25 mg/ml View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 25 µg View All» Format: Purified View All» Host: Mouse View All»
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