货号：05-374

品牌：Merck Millipore

规格：

目录价：￥3639.00

市场价格：￥3093.15

会员价格：￥2911.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Cyclin A Antibody, clone BF 683 | 05-374 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Cyclin A View All» Molecular Weight: 58kDa View All» Immunogen: Recombinant human Cyclin A1. View All» Isotype: IgG1 View All» Species Reactivity: Human View All» Quality Assurance: routinely evaluated in immunoblot on HeLa nuclear extract, or human A431 cells View All» Purification Method: Protein G chromatography View All» Presentation: mouse monoclonal IgG1 containing 0.05% sodium azide View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: P78396 View All» Entrez Gene Number: NM_001237 View All» Gene Symbol:

• CCNA1

• Cyclin-A1.
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Immunoprecipitation

  • Western Blotting
    View All» Entrez Gene Summary: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. View All» UniProt Summary: FUNCTION: SwissProt: P78396 # May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells.SIZE: 465 amino acids; 52358 Da SUBUNIT: Interacts with the CDK2 and the CDC2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Does not bind CDK4 and CDK5 (in vitro). The cyclin A1-CDK2 complex interacts with transcription factor E2F-1 and RB proteins. Found in a complex with CDK2, CABLES1 and CCNE1 (By similarity). Interacts with KLHDC9.TISSUE SPECIFICITY: Very high levels in testis and very low levels in brain. Also found in myeloid Leukemia cell lines.DEVELOPMENTAL STAGE: Expression increases in early G1 phase and reaches highest levels during the S and G2/M phases.SIMILARITY: SwissProt: P78396 ## Belongs to the cyclin family. Cyclin AB subfamily. View All» Brand Family: Upstate View All» Product Name: Anti-Cyclin A Antibody, clone BF 683 | 05-374 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 250 µL View All» Format: Purified View All» Host: Mouse View All»
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