货号：05-378

品牌：Merck Millipore

规格：

目录价：￥4264.00

市场价格：￥3624.40

会员价格：￥3411.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-RhoGAP p190 Antibody, clone D2D6 | 05-378 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes RhoGAP, MW ~190kDa. View All» Molecular Weight: ~190 kDa View All» Immunogen: GST-fusion protein to amino acids 180-610 of rat p190 RhoGAP. View All» Clone: D2D6 View All» Isotype: IgG View All» Background Information: RhoGAP p190 (Rho GTPase Activating Protein 5, ARHGAP5), like other RhoGAPs, stimulates the intrinsic GTPases activity of Rho, Rac, and Cdc42, but shows definite preference for Rho. RhoGAP p190 contains an N-terminal GTPase domain and a C-terminal RhoGAP domain. The activity of RhoGAP p190 is known to be regulated by phosphorylation, by kinases such as Src that is stimulated by growth factor signaling or cell attachment and phosphorylate RhoGAP p190 in its central region. This ultimately leads to reduced RHO-GTP and decreased stress fibers. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Monkey
  View All» Species Reactivity Note: Human, mouse, monkey and rat. View All» Application Notes: Immunoprecipitation: 4 μg of a previous lot immunoprecipitated RhoGAP from 500 μg of human A431 carcinoma cell RIPA lysate. View All» Control: Included Positive Antigen Control: Catalog # 12-301, non-stimulated A431 cell lysate. Add 2.5 μL of 2-mercaptoethanol/100 μL of lysate and boil for 5 minutes to reduce the preparation. Use 20 μg per lane for minigels. View All» Quality Assurance: Evaluated in immunoblot on RIPA lysates from human A431 carcinoma cells, mouse 3T3 fibroblasts or rabbit brain membrane extract.Western Blot Analysis: 0.5-2 μg/mL of this antibody detected RhoGAP in RIPA lysates from human A431 carcinoma cells. Previous lots of the antibody detected RhoGAP in mouse 3T3 fibroblasts and a rabbit brain membrane extract. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG in buffer containing 0.1 M Tris-glycine, pH 7.4, 0.15 M NaCl with 0.05% sodium azide. Frozen solution. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt. View All» UniProt Number: Q07960 View All» Entrez Gene Number: NM_004308 View All» Gene Symbol:
  • ARHGAP1

  • RHOGAP

  • p50-RhoGAP

  • CDC42GA1

  • CDC42GAP

  • Cdc42GAP

  • p50rhoGAP

  • RHOGAP1

  • RhoGAP
    View All» Alternate Names:
    • CDC42 GTPase-activating protein

    • GTPase-activating protein rhoOGAP

    • Rho GTPase activating protein 1

    • Rho-related small GTPase protein activator

    • Rho-type GTPase-activating protein 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunoprecipitation

      • Western Blotting
        View All» UniProt Summary: FUNCTION: SwissProt: Q07960 # GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate.SIZE: 439 amino acids; 50436 Da SUBUNIT: Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with BNIPL.SUBCELLULAR LOCATION: Cytoplasm.TISSUE SPECIFICITY: Ubiquitous.SIMILARITY: SwissProt: Q07960 ## Contains 1 CRAL-TRIO domain. & Contains 1 Rho-GAP domain. View All» Brand Family: Upstate View All» Product Name: Anti-RhoGAP p190 Antibody, clone D2D6 | 05-378 View All» Concentration: 0.88 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 200 μg View All» Format: Purified View All» Host: Mouse View All»
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