货号：05-386

品牌：Merck Millipore

规格：200Ug

目录价：￥5666.00

市场价格：￥4816.10

会员价格：￥4532.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Vinculin Antibody, clone V284 | 05-386 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Vinculin View All» Molecular Weight: 117kDa View All» Immunogen: Human Vinculin View All» Isotype: IgG1 View All» Species Reactivity:

• Chicken

• Human

• Mouse

• Rat

• Rabbit
  View All» Quality Assurance: routinely evaluated by immunoblot on RIPA lysates of human A431 cells, lysates from chicken embryonic fibroblasts (CEF), or mouse 3T3/A31 fibroblasts View All» Purification Method: Protein A chromatography View All» Presentation: PBS, pH 7.4, containing 0.05% sodium azide and 1mg/ml BSA View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: P18206 View All» Entrez Gene Number: NM_003373 View All» Gene Symbol:
  • VCL

  • Metavinculin

  • OTTHUMP00000043885

  • vinculin

  • MVCL

  • Vinculin
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunoprecipitation

    • Western Blotting

    • Immunohistochemistry
      View All» Entrez Gene Summary: Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. Human vinculin protein exhibits a greater than 95% sequence identity to the chicken vinculin protein. View All» UniProt Summary: FUNCTION: SwissProt: P18206 # Involved in cell adhesion. May be involved in the attachment of the actin-based microfilaments to the plasma membrane. May also play important roles in cell morphology and locomotion.SIZE: 1134 amino acids; 123799 Da SUBUNIT: Exhibits self-association properties. Interacts with NRAP and SORBS1 (By similarity). Interacts with TLN1.SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell junction, adherens junction; Cytoplasmic side. Note=Cytoplasmic face of adhesion plaques.TISSUE SPECIFICITY: Metavinculin is muscle-specific.PTM: Phosphorylated on serines, threonines and tyrosines and acylated by myristic acid and/or palmitic acid.DISEASE:SwissProt: P18206 # Defects in VCL are a cause of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM).SIMILARITY: SwissProt: P18206 ## Belongs to the vinculin/alpha-catenin family. View All» Brand Family: Upstate View All» Product Name: Anti-Vinculin Antibody, clone V284 | 05-386 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 200 µg View All» Format: Purified View All» Host: Mouse View All»
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