货号：05-406

品牌：Merck Millipore

规格：200Ug

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-JAK3 Antibody, clone B32-32 | 05-406 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: JAK3 View All» Molecular Weight: 125kDa View All» Immunogen: GST-fusion protein containing amino acids 1076-1100 of murine thymus JAK3. Clone B32-32. View All» Clone: B32-32 View All» Isotype: IgG2bκ View All» Species Reactivity:

• Human

• Mouse
  View All» Application Notes: Not recommended for WB. View All» Quality Assurance: routinely evaluated by immunoprecipitation of JAK3 from CTLL cells or from TF-1 RIPA cell lysate View All» Purification Method: Protein A chromatography View All» Presentation: 0.1M Tris-glycine, pH 7.4, 0.15M NaCl containing 0.05% sodium azide View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: P52333 View All» Entrez Gene Number: NM_000215 View All» Gene Symbol:
  • JAK3

  • LJAK

  • L-JAK

  • JAK-3

  • JAKL

  • JAK3_HUMAN
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Immunoprecipitation View All» Entrez Gene Summary: JAK3 encodes Janus kinase 3, a tyrosine kinase that belongs to the Janus family. JAK3 functions in signal transduction and interacts with members of the STAT (signal transduction and activators of transcription) family. JAK3 is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations that abrogate Janus kinase 3 function cause an autosomal SCID (severe combined immunodeficiency disease). View All» UniProt Summary: FUNCTION: SwissProt: P52333 # Tyrosine kinase of the non-receptor type, involved in the interleukin-2 and interleukin-4 signaling pathway. Phosphorylates STAT6, IRS1, IRS2 and PI3K.SIZE: 1124 amino acids; 125099 Da SUBUNIT: Interacts with STAM2 and MYO18A (By similarity). Interacts with SHB.SUBCELLULAR LOCATION: Intracytoplasmic membrane; Peripheral membrane protein (By similarity). Note=Wholly intracellular, possibly membrane associated (By similarity).TISSUE SPECIFICITY: In NK cells and an NK-like cell line but not in resting T-cells or in other tissues. The S-form is more commonly seen in hematopoietic lines, whereas the B- and M-forms are detected in cells both of hematopoietic and epithelial origins.DOMAIN: SwissProt: P52333 Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity), while the presence of slight differences suggest a different role for domain 1.PTM: Tyrosine phosphorylated in response to IL-2 and IL-4.DISEASE: SwissProt: P52333 # Defects in JAK3 are a cause of autosomal recessive T-cell negative/B-cell positive type of severe combined immunodeficiency (SCID) [MIM:600802]; a condition characterized by the absence of circulating mature T-lymphocytes and NK cells, normal to elevated numbers of nonfunctional B-lymphocytes, and marked hypoplasia of lymphoid tissues.SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. & Contains 1 FERM domain. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. View All» Brand Family: Upstate View All» Product Name: Anti-JAK3 Antibody, clone B32-32 | 05-406 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 200 µg View All» Format: Purified View All» Host: Mouse View All»
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