货号：05-414

品牌：Merck Millipore

规格：100Ug

目录价：￥6281.00

市场价格：￥5338.85

会员价格：￥5024.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-CrkL Antibody, clone 5-6 | 05-414 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: the C-terminal SH3 of Human CRKL View All» Molecular Weight: 39kDa View All» Epitope: Full-length View All» Immunogen: Full length GST fusion protein corresponding to Human CRKL View All» Clone: 5-6 View All» Isotype: IgG2aκ View All» Background Information: CRKL is a 39kDa adaptor protein with one SH2 and two SH3 binding domains. CRKL is the major protein which is tyrosine phosphorylated in response to BCR/ABL (chronic myelogenous leukemia) and growth factor activation. In myeloid cells, it binds to proteins such as paxillin, p130cas and p120 cbl. CRKL aslo appears to bind ABL and SOS.The antibody does not cross-react with CRKI or CRKII. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Reacts with human, mouse and rat. Other species have not been tested. View All» Control: Western Blot and Immunoprecipitation:K562 cell lysateImmunocytochemistry: Hela cells View All» Quality Assurance: Routinely evaluated by Western Blot on K562 cell lysate.Western Blot Analysis: Antibody detected CRKL in 15 μg of K562 cell lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3. View All» Storage Conditions: Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt. View All» UniProt Number: P46109 View All» Entrez Gene Number: NM_005207 View All» Gene Symbol: CRKL View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Immunoprecipitation

  • Western Blotting

  • Immunohistochemistry
    View All» Entrez Gene Summary: v-CRK avian sarcoma virus CT10-homolog-like contains one SH2 domain and two SH3 domains. CRKL has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase and plays a role in fibroblast transformation by BCR-ABL. In addition, CRKL has oncogenic potential. View All» UniProt Summary: FUNCTION: SwissProt: P46109 # May mediate the transduction of intracellular signals.SIZE: 303 amino acids; 33777 Da SUBUNIT: Interacts with INPP5D/SHIP1. Interacts with DOCK2 and EPOR. Interacts with phosphorylated CBLB.SIMILARITY: SwissProt: P46109 ## Contains 1 SH2 domain. & Contains 2 SH3 domains. View All» Brand Family: Upstate View All» Product Name: Anti- CRKL, Clone 5-6 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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