货号：05-432A4

品牌：Merck Millipore

规格：

目录价：￥4774.00

市场价格：￥4057.90

会员价格：￥3819.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-NR1 Antibody, C Terminus, Alexa Fluor®488 Conjugate | 05-432A4 View All» Promotional Text: Special Offer on Antibodies! Click Here! View All» Specificity: This antibody maps to a region (834-864) common to all NR1 isoforms and so should cross react with all NR1 isoforms. View All» Molecular Weight: Uniprot describes isoforms at 99-108 kDa. The unconjugated parent antibody (Cat. No. 05-432) has an observed molecular weight at ~130 kDa. View All» Epitope: This antibody maps to a region (a.a. 834-864) common to all NR1 isoforms View All» Immunogen: Recombinant protein corresponding to rat NR1. View All» Isotype: IgG View All» Background Information: NR1 (NMDA1or NMDAR1, also known as GRIN1) along with the NR2 subunit forms a heterodimer that make up the NMDA receptor. The NMDA receptor (NMDAR) is characterized as a ionotropic receptor for glutamate. As the name suggests, NMDA (N-methyl D-aspartate) is an agonist for the receptor. A distinct characteriztic of the NMDA receptor is that it is both ligand-gated and voltage-dependent based on its sensitivity to magnesium. Activated NMDA receptors result in the opening of an ion channel that is nonselective to cations. The result is the flow of Na+ and small amounts of Ca2+ ions into the cell and K+ out of the cell. Calcium flux by the NMDARs has been implicated in synaptic plasticity, a mechanism in the cell for learning and memory. View All» Species Reactivity:

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Mouse and Rat. Predicted to react with Human based on 100% sequence homology. View All» Control: Mouse adult brain tissue View All» Quality Assurance: Evaluated by Immunohistochemistry in mouse adult brain tissue.Immunohistochemistry Analysis: 1:100 dilution of this antibody detected NR1 in mouse adult brain tissue. View All» Purification Method: Protein G Purified View All» Presentation: Purified mouse monoclonal IgG conjugated to Alexa Fluor® 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA. View All» Storage Conditions: Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt. View All» UniProt Number: P35439 View All» Entrez Gene Number: NP_058706 View All» Gene Symbol:
  • Grin1

  • Nmdar1
    View All» Alternate Names:
    • Glutamate [NMDA] receptor subunit zeta-1

    • N-methyl-D-aspartate receptor subunit NR1

    • NMD-R1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunocytochemistry

      • Immunohistochemistry
        View All» Entrez Gene Summary: Subunit of NMDA-preferring ionotropic glutamate receptors; may play a role in long term potentiation [RGD]. View All» UniProt Summary: FUNCTION: NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.SUBUNIT: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B); disulfide-linked. Found in a complex with GRIN2A or GRIN2B, GRIN3A or GRIN3B and PPP2CB. Interacts with DLG4 and MPDZSUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein, Cell junction › synapse › postsynaptic cell membrane. Cell junction › synapse › postsynaptic cell membrane › postsynaptic density. Note: Enriched in post-synaptic plasma membrane and post-synaptic densities.POST-TRANSLATIONAL MODIFICATION: NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity.SIZE: 938 amino acids; 105,509 Da View All» Product Name: Anti-NR1, C Terminus, Alexa Fluor®488 Conjugate View All» Qty/Pk: 100 µL View All» Format: AlexaFluor®488 View All» Host: Mouse View All»
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