货号：05-473

品牌：Merck Millipore

规格：EA

目录价：￥4288.00

市场价格：￥3644.80

会员价格：￥3430.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-TRADD Antibody, clone 3E11 | 05-473 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: TRADD View All» Molecular Weight: 34kDa View All» Immunogen: Recombinant protein corresponding to full length (residues 1-312) human TRADD View All» Isotype: IgG2aκ View All» Species Reactivity: Human View All» Quality Assurance: routinely evaluated by immunoblot on RIPA lysates from A431 cells View All» Purification Method: Protein A chromatography View All» Presentation: Lyophilized powder View All» Storage Conditions: Lyophilized: 2 years at 4°C; Rehydrated: 3 months at -20°C View All» UniProt Number: Q15628 View All» Entrez Gene Number: NM_003789 View All» Gene Symbol:

• TRADD

• MGC11078

• Hs.89862
  View All» Sales Restrictions: This product is not available for sale in Japan. View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Immunoprecipitation

  • Western Blotting
    View All» Entrez Gene Summary: The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. View All» UniProt Summary: FUNCTION: SwissProt: Q15628 # Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.SIZE: 312 amino acids; 34247 Da SUBUNIT: Heterodimer with TNFRSF1A/TNFR1. Interacts with DAB2IP, FADD, HIPK2, KRT14, KRT16, KRT17, KRT18, RIPK1, SQSTM1, TRAF1, TRAF2 and TRPC4AP.SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.TISSUE SPECIFICITY: Found in all examined tissues.DOMAIN:SwissProt: Q15628 Requires the intact DEATH domain to associate with TNFRSF1A/TNFR1.SIMILARITY: Contains 1 death domain. View All» Brand Family: Upstate View All» Product Name: Anti-TRADD Antibody, clone 3E11 | 05-473 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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