货号：05-476

品牌：Merck Millipore

规格：

目录价：￥3346.00

市场价格：￥2844.10

会员价格：￥2676.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Itk/Emt/Tsk Antibody, clone 2F12 | 05-476 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Itk View All» Molecular Weight: 72kDa View All» Immunogen: GST fusion-protein corresponding to residues 1-26 of Itk/Emt/Tsk View All» Isotype: IgG1 View All» Background Information: ITK is a T cell signaling protein. The Tec family of non receptor tyrosine kinases is composed of six proteins designated Tec, ITK (also known as Emt or Tsk), Btk (previously known as Atk, BPK or Emb), Bmx, Txk (also known as Rlk) and Dsrc28C. All members of the family contain SH3 and SH2 domains and, with the exception of Txk and Dsrc28C, also contain pleckstrin homology (PH) and Tec homology (TH) domains in their amino termini. ITK associates with CD28 and becomes activated subsequent to CD28 ligation. View All» Species Reactivity:

• Human

• Mouse
  View All» Control: Jurkat cell lysate, K562 and A431 cell lysates, normal lymph node tissue View All» Quality Assurance: routinely evaluated by immunoblot on RIPA lysates from Jurkat cells View All» Purification Method: Ascites View All» Presentation: PBS, containing 0.02% sodium azide View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: Q08881 View All» Entrez Gene Number: NM_005546 View All» Gene Symbol:
  • ITK

  • LYK

  • PSCTK2

  • EMT

  • MGC126258

  • MGC126257
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunoprecipitation

    • Western Blotting
      View All» Entrez Gene Summary: This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. View All» UniProt Summary: FUNCTION: SwissProt: Q08881 # Plays a role in T-cell proliferation and differentiation.COFACTOR: Binds 1 zinc ion per subunit (By similarity).SIZE: 620 amino acids; 71831 Da SUBCELLULAR LOCATION: Cell membrane (By similarity). Note=Localizes to cell surface receptors in the plasma membrane after stimulation with respective receptors (TCR, CD28, CD2) in T- cells (By similarity).TISSUE SPECIFICITY: T-cell lines and natural killer cell lines.SIMILARITY: SwissProt: Q08881 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily. & Contains 1 Btk-type zinc finger. & Contains 1 PH domain. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain. View All» Brand Family: Upstate View All» Product Name: Anti-Itk/Emt/Tsk Antibody, clone 2F12 | 05-476 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Ascites View All» Host: Mouse View All»
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