货号：05-486

品牌：Merck Millipore

规格：100Ug

目录价：￥6434.00

市场价格：￥5468.90

会员价格：￥5147.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-FADD Antibody, clone 1F7 | 05-486 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: FADD View All» Molecular Weight: 28kDa View All» Immunogen: GST-tagged full-length fusion protein corresponding to human FADD View All» Isotype: IgG1 View All» Species Reactivity:

• Human

• Mouse
  View All» Quality Assurance: routinely evaluated by immunoblot on RIPA lysates from Jurkat cells View All» Purification Method: Protein A chromatography View All» Presentation: PBS, pH 7.2 and 50% glycerol View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: Q13158 View All» Entrez Gene Number: NM_003824 View All» Gene Symbol:
  • FADD

  • GIG3

  • MGC8528

  • MORT1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. View All» UniProt Summary: FUNCTION: SwissProt: Q13158 # Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis.SIZE: 208 amino acids; 23279 Da SUBUNIT: Interacts with CFLAR, PEA15 and MBD4. When phosphorylated, part of a complex containing HIPK3 and FAS. May interact with MAVS/IPS1. Interacts with MOCV v-CFLAR protein and LRDD.TISSUE SPECIFICITY: Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.DOMAIN:SwissProt: Q13158 Contains a death domain involved in the binding of the corresponding domain within Fas receptor.PTM: Phosphorylated.SIMILARITY: Contains 1 death domain. & Contains 1 DED (death effector) domain. View All» Brand Family: Upstate View All» Product Name: Anti-FADD Antibody, clone 1F7 | 05-486 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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