货号：05-507

品牌：Merck Millipore

规格：100Ug

目录价：￥4239.00

市场价格：￥3603.15

会员价格：￥3391.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Cdc25C Antibody, clone TC-15 | 05-507 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: cdc25C View All» Molecular Weight: 58kDa View All» Immunogen: GST fusion-protein corresponding to residues 1-258 of human cdc25C. Epitope mapped to residues 222-246. View All» Isotype: IgG1κ View All» Background Information: The activity of cyclin-dependent kinases is regulated by their phosphorylation status, which is controlled by the antagonistic action of CDC25 phosphatases. Three CDC25 genes are present in human cells: CDC25A, CDC25B and CDC25C. CDC25C is a ~56 kDa dual specific protein phosphatase that controls entry into mitosis by regulating the dephosphorylation of the Cdk1/cyclin B complex. Phosphorylation of Cdc25C creates a binding site for 14-3-3 protein which inhibits Cdc25C. This prevents activation of the Cdk1/cyclin B complex and prevents mitotic entry. Cdc25C is phosphorylated by checkpoint kinases throughout interphase but becomes dephosphorylated during mitosis. Cdc25C is also regulated by p53 via a p53 response element in its promoter, and it is predominantly expressed in the G2 phase of the cell cycle. View All» Species Reactivity:

• Human

• Mouse
  View All» Control: HeLa nuclear extract View All» Quality Assurance: routinely evaluated by immunoblot on HeLa nuclear extract View All» Purification Method: Protein G chromatography View All» Presentation: 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: P30307 View All» Entrez Gene Number: NM_001790 View All» Gene Symbol:
  • CDC25C

  • CDC25
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunoprecipitation

    • Western Blotting

    • Immunocytochemistry
      View All» Entrez Gene Summary: This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known. View All» UniProt Summary: FUNCTION: SwissProt: P30307 # Functions as a dosage-dependent inducer in mitotic control. It is a tyrosine protein phosphatase required for progression of the cell cycle. It directly dephosphorylates CDC2 and activate its kinase activity.SIZE: 473 amino acids; 53365 Da SUBUNIT: Interacts with HIV-1 Vpr, thereby inactivating CDC25C phosphatase activity.SUBCELLULAR LOCATION: Nucleus.DEVELOPMENTAL STAGE: Expressed predominantly in G2 phase.PTM: Phosphorylated by CHK1 on Ser-216. This phosphorylation creates a binding site for 14-3-3 protein and inhibits the phosphatase.SIMILARITY: SwissProt: P30307 ## Belongs to the MPI phosphatase family. & Contains 1 rhodanese domain. View All» Brand Family: Upstate View All» Product Name: Anti-Cdc25C Antibody, clone TC-15 | 05-507 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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