货号：05-521

品牌：Merck Millipore

规格：100Ug

目录价：￥5062.00

市场价格：￥4302.70

会员价格：￥4049.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-TRF2 Antibody, clone 4A794 | 05-521 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes TRF2. View All» Molecular Weight: 66 kDa View All» Immunogen: His-tagged, fusion-protein, corresponding to full-length TRF2 (Telomeric Repeat binding Factor 2), expressed in baculovirus View All» Clone: 4A794 View All» Isotype: IgG1 View All» Background Information: TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length. TRF2, like TRF1, contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localised to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types. TRF2 is overexpressed in a number of human tumors and overexpression of TRF2 has been shown to be oncogenic in a mouse model of carcinogenesis. View All» Species Reactivity:

• Human

• Rat
  View All» Control: Positive Control Included: Jurkat cell lysate (12-303) View All» Quality Assurance: routinely evaluated by immunoblot on RIPA lysate of human Jurkat cells, HeLa nuclear extract, or rat L6 RIPA cell lysate View All» Purification Method: Protein G purfied View All» Presentation: Protein G Purified immunoglobulin in Immunoaffinity Purified immunoglobulin in 150mM Tris/glycine, 0.05% sodium azide, 5mg/ml BSA before the addition of glycerol to 30% View All» Storage Conditions: Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: Q15554 View All» Entrez Gene Number: NM_005652 View All» Gene Symbol:
  • TERF2

  • TRF2

  • TRBF2
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunocytochemistry

    • Western Blotting
      View All» Entrez Gene Summary: This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic. View All» UniProt Summary: FUNCTION: SwissProt: Q15554 # Binds the telomeric double-stranded TTAGGG repeat. Protects against end-to-end fusion of chromosomes and plays a role in successful progression through the cell division cycle.SIZE: 500 amino acids; 55551 Da SUBUNIT: Homodimer. Binds to RAP1. Interacts with NBN.SUBCELLULAR LOCATION: Nucleus. Note=Colocalizes with telomeric DNA in interphase cells and is located at chromosome ends during metaphase.TISSUE SPECIFICITY: Ubiquitous. Highly expressed in spleen, thymus, prostate, uterus, testis, small intestine, colon and peripheral blood leukocytes.PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.SIMILARITY: SwissProt: Q15554 ## Contains 1 HTH myb-type DNA-binding domain. View All» Brand Family: Upstate View All» Product Name: Anti-TRF2 Antibody, clone 4A794 | 05-521 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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