货号：05-522

品牌：Merck Millipore

规格：

目录价：￥4072.00

市场价格：￥3461.20

会员价格：￥3257.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SRC-1 Antibody, clone 1135 | 05-522 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: SRC-1 isoforms View All» Molecular Weight: 160kDa View All» Immunogen: GST fusion-protein containing amino acids 477-947 of human SRC-1 (Steroid Receptor Coactivator-1) View All» Isotype: IgG1κ View All» Background Information: Steroid Receptor Coactivator-1 (SRC-1) is a member of a gene family that functions in the full transcriptional activation of the steroid hormone receptor superfamily and contains intrinsic histone acetyltransferase activity. SRC-1 has a molecular weight of 160 kDa and has a basic helix-loop-helix (bHLH)-PAS domain. SRC-1 is also known as Nuclear receptor coactivator 1 (NCoA-1). View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Control: Cos-1 cell lysate View All» Quality Assurance: routinely evaluated by immunoblot on Cos-1 cell lysate or HeLa Nuclear Extract View All» Purification Method: Protein G chromatography View All» Presentation: 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: Q15788 View All» Entrez Gene Number: NM_003743 and others View All» Gene Symbol: NCOA1 View All» Alternate Names:
  • NCoA-1

  • SRC1

  • SRC-1

  • KAT13A

  • RIP160

  • MGC129719

  • MGC129720
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunoprecipitation

    • Western Blotting
      View All» Entrez Gene Summary: This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. View All» UniProt Summary: SIZE: 536 amino acids; 59835 Da SUBUNIT: Interacts with DDEF1/ASAP1 via its SH3 domain. Interacts with CCPG1 (By similarity). Interacts with CDCP1, PELP1, TGFB1I1 and TOM1L2.PTM: Phosphorylated on Tyr-530 by c-Src kinase (CSK). The phosphorylated form is termed pp60c-src. The phosphorylated tail interacts with the SH2 domain thereby repressing kinase activity.SIMILARITY: SwissProt: P12931 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain. View All» Brand Family: Upstate View All» Product Name: Anti-SRC-1 Antibody, clone 1135 | 05-522 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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