货号：05-584

品牌：Merck Millipore

规格：200Ug

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Tie2/TEK Antibody, clone Ab33 | 05-584 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes Tie2/TEK, Mr 145kDa View All» Molecular Weight: 145 kDa View All» Immunogen: Fusion protein corresponding to residues 1-745 of human Tie2/TEK with a C-terminal His6-tag purified from infected SF-9 cells. Clone Ab33 View All» Clone: clone Ab33 View All» Isotype: IgG1κ View All» Background Information: TIE2 (tyrosine kinase with Ig and EGF homology domains 2) is expressed almost exclusively in endothelial cells in mice, rats and humans. This receptor possesses a unique extracellular domain containing two immunoglobulin-like loops separated by three epidermal growth factor-like repeats that are connected to three fibronectin type III-like repeats. The ligand for the receptor is Angiopoietin 1. Defects in TIE2 are associated with inherited venous malformations; the TIE2 signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Pig
  View All» Species Reactivity Note: Human, mouse, rat, and pig. View All» Application Notes: Immunoprecipitation: This antibody immunoprecipitated Tie2/TEK, as reported by an independent laboratory.Immunohistochemistry: Reported to detect Tie2/TEK in frozen, Triton-treated sections. This antibody is not suitable for paraffin-embedded sections. View All» Control: HUVEC cell lysate View All» Quality Assurance: Evaluated by western blot on RIPA lysates from HUVEC cells.Western Blot Analysis: 0.2-1 μg/mL of this antibody detected Tie2/TEK in RIPA lysates from HUVEC cells. View All» Purification Method: Protein G purfied View All» Presentation: Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-glycine, pH 7.4, 0.15 M NaCl, 0.05% sodium azide before the addition of glycerol to 30%. Liquid at -20°C. View All» Storage Conditions: Stable for 1 year at from date of receipt. View All» UniProt Number: Q02763 View All» Entrez Gene Number: NM_000459 View All» Gene Symbol:
  • TEK

  • CD202B

  • TIE2

  • VMCM1

  • VMCM

  • hTIE2

  • CD202b

  • TIE-2
    View All» Alternate Names:
    • CD202b antigen

    • TEK tyrosine kinase, endothelial

    • Tunica interna endothelial cell kinase

    • Tyrosine-protein kinase receptor TEK

    • Tyrosine-protein kinase receptor TIE-2

    • p140 TEK

    • soluble TIE2 variant 1

    • soluble TIE2 variant 2venous malformations, multiple cutaneous and mucosal
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunoprecipitation

      • Immunohistochemistry
        View All» Entrez Gene Summary: The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase. View All» UniProt Summary: FUNCTION: SwissProt: Q02763 # This protein is a protein tyrosine-kinase transmembrane receptor for angiopoietin 1. It may constitute the earliest mammalian endothelial cell lineage marker. Probably regulates endothelial cell proliferation, differentiation and guides the proper patterning of endothelial cells during blood vessel formation.SIZE: 1124 amino acids; 125811 Da SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Predominantly expressed in endothelial cells and their progenitors, the angioblasts. Has been directly found in placenta and lung, with a lower level in umbilical vein endothelial cells, brain and kidney.DISEASE:SwissProt: Q02763 # Defects in TEK are a cause of dominantly inherited venous malformations (VMCM) [MIM:600195]; an error of vascular morphogenesis characterized by dilated, serpiginous channels.SIMILARITY: SwissProt: Q02763 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily. & Contains 3 EGF-like domains. & Contains 3 fibronectin type-III domains. & Contains 2 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain. View All» Brand Family: Upstate View All» Product Name: Anti-Tie2/TEK Antibody, clone Ab33 | 05-584 View All» Concentration: 1 mg/mL View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 200 μg View All» Format: Purified View All» Host: Mouse View All»
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