货号：05-590

品牌：Merck Millipore

规格：100Ug

目录价：￥5249.00

市场价格：￥4461.65

会员价格：￥4199.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-STAT6 (Tyr641) Antibody, clone 16E12 | 05-590 View All» Replaces: MAB3702 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: phosphorylated STAT6 View All» Molecular Weight: 100kDa View All» Immunogen: Peptide corresponding to residues of human STAT6 (Tyr641); recognizes STAT6 phosphorylated on Tyrosine 641. View All» Modifications: Phosphorylation View All» Isotype: IgG1 View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Quality Assurance: routinely evaluated by immunoblot on RIPA lysates from IL4-stimulated HepG2 cells View All» Purification Method: Thiophilic adsoption and size exclusion chromatography View All» Presentation: 100µg of lyophilized thiophilic and size exclusion chromatography purified mouse IgG1 from 1mL 2x PBS / 0.09 % Na-azide / PEG and Sucrose. Reconstitute with 100 µL H2O (15 min, RT) for a final concentration of 1 mg/mL. Store at -20°C. View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: P42226 View All» Entrez Gene Number: NM_003153 View All» Gene Symbol:
  • STAT6

  • STAT6C

  • D12S1644

  • STAT6B

  • IL-4-STAT
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. View All» UniProt Summary: FUNCTION: SwissProt: P42226 # Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling.SIZE: 847 amino acids; 94135 Da SUBUNIT: Forms a homodimer or a heterodimer with a related family member (By similarity). Interacts with NCOA1 via its C-terminal LXXLL motif.SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.PTM: Tyrosine phosphorylated following stimulation by IL-4 and IL- 3 (By similarity).SIMILARITY: SwissProt: P42226 ## Belongs to the transcription factor STAT family. & Contains 1 SH2 domain. View All» Brand Family: Upstate View All» Product Name: Anti-phospho-STAT6 (Tyr641) Antibody, clone 16E12 | 05-590 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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