货号：05-618

品牌：Merck Millipore

规格：

目录价：￥4118.00

市场价格：￥3500.30

会员价格：￥3294.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-WAVE1/Scar1 Antibody, clone 84.79 | 05-618 View All» Replaces: MAB3704 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: WAVE1 View All» Molecular Weight: 84kDa View All» Immunogen: His6 fusion protein corresponding to full-length rat WAVE1 View All» Clone: 84.79 View All» Isotype: IgG View All» Species Reactivity: Rat View All» Quality Assurance: routinely evaluated by immunoblot on rat brain cytosol View All» Purification Method: Ascites View All» Presentation: mouse ascites with 0.05% sodium azide and 30% glycerol added View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: Q92558 View All» Entrez Gene Number: NM_003931 View All» Gene Symbol:

• WASF1

• FLJ31482

• SCAR1

• WAVE1

• KIAA0269

• WAVE
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. View All» UniProt Summary: FUNCTION: SwissProt: Q92558 # Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton.SIZE: 559 amino acids; 61652 Da SUBUNIT: Component of the WAVE1 complex composed of ABI2, CYFIP2, C3orf10/HSPC300, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1 (By similarity). Binds actin and the Arp2/3 complex. Interacts with BAIAP2.SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Note=Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane- ruffling areas.TISSUE SPECIFICITY: Highly expressed in brain. Lowly expressed in testis, ovary, colon, kidney, pancreas, thymus, small intestine and peripheral blood.DOMAIN:SwissProt: Q92558 Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain.SIMILARITY: Contains 1 WH2 domain. View All» Brand Family: Upstate View All» Product Name: Anti-WAVE1/Scar1 Antibody, clone 84.79 | 05-618 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Ascites View All» Host: Mouse View All»
  © 金山科研平台是专业的授权总代理区域代理经销平台。
  © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
  © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
  © 本文地址：https://www.16ao.com/thread-133902.htm
  © Merck Millipore代理05-618 Anti-WAVE1, clone 84.79，产品报价联系微信jinshanbio