货号：05-637

品牌：Merck Millipore

规格：100Ug

目录价：￥7049.00

市场价格：￥5991.65

会员价格：￥5639.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Bmi-1 Antibody, clone F6 | 05-637 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes Bmi-1 (triplet). View All» Molecular Weight: 40-44 kDa View All» Immunogen: Immunized with recombinant Bmi-1 protein corresponding to residues 1-202 of mouse Bmi-1. View All» Clone: F6 View All» Isotype: IgG1 View All» Background Information: The Bmi1 protein is a member of the polycomb group (PcG) proteins. PcG proteins form multiprotein complexes that function as transcriptional repressors. Several lines of evidence implicate Bmi1 in tumorigenesis. Firstly, Bmi1 cooperates with c-Myc in the generation of lymphomas in double transgenic mice. Secondly, Bmi1 blocks senescence and immortalizes mouse embryo fibroblasts, although not human fibroblasts, and in combination with an activated H-ras gene leads to neoplastic transformation. Thirdly, the BMI1 gene is amplified in certain mantle cell lymphomas and is overexpressed in a subset of non-small cell lung cancer, colorectal carcinomas, multiple myelomas and medulloblastomas, but not glioblastomas. Fourthly, the transformation of human hematopoietic progenitor cells by the oncogenic fusion protein E2a-Pbx1 requires Bmi1. Indeed, based on a list of genes differentially expressed in a mouse model of metastatic prostate cancer on a wild-type and bmi1-deficient genetic background a gene signature was recently identified that may predict response to therapy and survival in multiple types of cancer. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Rabbit
  View All» Control: U2OS whole cell lysate, K-562 nuclear extract, 0-4 hour embryos or 12-24 hour embryos View All» Quality Assurance: routinely evaluated by immunoblot on RIPA lysates from U2OS cells. View All» Purification Method: Protein G purfied View All» Presentation: Immunoaffinity Purified immunoglobulin in Protein A Purified immunoglobulin in 0.1M Tris-Glycine, 0.15M NaCl, 0.05% sodium azide, pH 7.4. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number:
  • P35226

  • P25916
    View All» Entrez Gene Number: NM_005180 View All» Gene Symbol:
    • BMI1

    • MGC12685

    • PCGF4

    • flvi-2/bmi-1

    • RNF51
      View All» Alternate Names: Polycomb group RING finger protein 4; RING finger protein 51 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunocytochemistry

      • Immunoprecipitation

      • Western Blotting
        View All» UniProt Summary: FUNCTION: SwissProt: P35226 # Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.SIZE: 326 amino acids; 36949 Da SUBUNIT: Component of chromatin-associated class II polycomb repressive complex 1 (PRC1/hPRC-H) at least composed of PCGF2/RNF110, BMI1/PCGF4, CBX2/M33, CBX4/PC2, CBX8/PC3, PHC1, PHC2, PHC3, SCMH1, RING1 and RNF2/RING2. Also component of E3 ubiquitin ligase complex or human polycomb repressive complex 1- like at least composed of PHC2, BMI1, RING1 and RNF2. Interacts with SPOP. Part of a complex consisting of BMI1, CUL3 and SPOP.SUBCELLULAR LOCATION: Nucleus.PTM: May be polyubiquitinated; which does not lead to proteasomal degradation.DISEASE:SwissProt: P35226 # Cooperates with the MYC oncogene to produce B-lymphomas.SIMILARITY: SwissProt: P35226 ## Contains 1 RING-type zinc finger. View All» Brand Family: Upstate View All» Product Name: Anti-Bmi-1 Antibody, clone F6 | 05-637 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Mouse View All»
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