货号：05-655

品牌：Merck Millipore

规格：200Ug

目录价：￥5207.00

市场价格：￥4425.95

会员价格：￥4165.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-p21/WAF1/Cip1 Antibody, clone CP74 | 05-655 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Cip1 View All» Molecular Weight: 21kDa View All» Immunogen: Recombinant full-length human Cip1 with an N-terminal histidine tag; epitope corresponds to amino acids 1-80 of full-length human Cip1 View All» Isotype: IgG2bκ View All» Species Reactivity: Human View All» Quality Assurance: routinely evaluated by immunoblot on nuclear extract from HeLa cells View All» Purification Method: Protein G purfied View All» Presentation: 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: P38936 View All» Entrez Gene Number: NM_000389 View All» Gene Symbol:

• CDKN1A

• MDA-6

• SDI1

• MDA6

• p21

• p21CIP1

• PIC1

• CIP1

• P21

• CDKN1

• WAF1

• CAP20
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported. View All» UniProt Summary: FUNCTION: SwissProt: P38936 # May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression.SIZE: 164 amino acids; 18119 Da SUBCELLULAR LOCATION: Cytoplasm. Nucleus.TISSUE SPECIFICITY: Expressed in all adult human tissues, with 5- fold lower levels observed in the brain.PTM: Phosphorylation of Thr-145 by Akt or of Ser-146 by PKC impairs binding to PCNA.SIMILARITY: SwissProt: P38936 ## Belongs to the CDI family. View All» Brand Family: Upstate View All» Product Name: Anti-p21/WAF1/Cip1 Antibody, clone CP74 | 05-655 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 200 µg View All» Format: Purified View All» Host: Mouse View All»
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