货号：05-756

品牌：Merck Millipore

规格：

目录价：￥4645.00

市场价格：￥3948.25

会员价格：￥3716.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Calsenilin/DREAM Antibody, clone 40A5 | 05-756 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Calsenilin/DREAM View All» Molecular Weight: ~30kDa View All» Immunogen: Full length GST fusion protein of human Calsenilin/DREAM View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Quality Assurance: routinely evaluated by immunoblot on RIPA homogenate from human Alzheimers diseased brain View All» Purification Method: Ascites View All» Presentation: 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: Q9Y2W7 View All» Entrez Gene Number: NM_013434 View All» Gene Symbol:
  • KCNIP3

  • MGC18289

  • KChIP3

  • DREAM

  • CSEN

  • calsenilin

  • Calsenilin

  • KCHIP3
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunoprecipitation

    • Western Blotting
      View All» Entrez Gene Summary: This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. View All» UniProt Summary: FUNCTION: SwissProt: Q9Y2W7 # May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of beta-amyloid formation.SIZE: 256 amino acids; 29231 Da SUBUNIT: Binds to DNA as a homomultimer. Dimerization is induced by binding to calcium. Component of heteromultimeric potassium channels. Interacts with KCND2 and KCND3 (By similarity). Interacts with the C-terminus of PSEN1 and PSEN2 and with PSEN2 CTF subunit. Associates with KCN1.SUBCELLULAR LOCATION: Cytoplasm. Cell membrane; Lipid-anchor (By similarity). Endoplasmic reticulum. Golgi apparatus. Nucleus (Probable). Note=Also membrane-bound, associated with the plasma membrane (By similarity). In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi.TISSUE SPECIFICITY: Highly expressed in brain. Widely expressed at lower levels. Expression levels are elevated in brain cortex regions affected by Alzheimer disease.PTM: Palmitoylated. Palmitoylation enhances association with the plasma membrane (By similarity). & Proteolytically cleaved by caspase-3.SIMILARITY: SwissProt: Q9Y2W7 ## Belongs to the recoverin family. & Contains 4 EF-hand domains. View All» Brand Family: Upstate View All» Product Name: Anti-Calsenilin/DREAM Antibody, clone 40A5 | 05-756 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Mouse View All»
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