货号：05-758

品牌：Merck Millipore

规格：EA

目录价：￥4140.00

市场价格：￥3519.00

会员价格：￥3312.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-FE65 Antibody, clone 3H6 | 05-758 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes FE65. View All» Molecular Weight: ~97 kDa View All» Immunogen: GST fusion protein corresponding to amino acids 254-293 of mouse FE65, WW domain View All» Clone: 3H6 View All» Isotype: IgG View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Control: Alzheimer's diseased brains View All» Quality Assurance: Routinely evaluated by immunoblot on homogenates prepared from whole mouse, rat and human Alzheimers diseased brains View All» Purification Method: Unpurified View All» Presentation: Immunoaffinity Purified immunoglobulin in 0.2M Tris-glycine, pH 7.2, 0.15M NaCl, 0.05% sodium azide with 5mg/ml BSA View All» Storage Conditions: Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: O00213 View All» Entrez Gene Number: NM_001164 View All» Gene Symbol:
  • APBB1

  • RIR

  • FE65

  • MGC:9072

  • Fe65
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunocytochemistry

    • Immunoprecipitation

    • Western Blotting
      View All» Entrez Gene Summary: The protein encoded by this gene is a member of the Fe65 protein family. It is an adaptor protein localized in the nucleus. It interacts with the Alzheimer's disease amyloid precursor protein (APP), transcription factor CP2/LSF/LBP1 and the low-density lipoprotein receptor-related protein. APP functions as a cytosolic anchoring site that can prevent the gene product's nuclear translocation. This encoded protein could play an important role in the pathogenesis of Alzheimer's disease. It is thought to regulate transcription. Also it is observed to block cell cycle progression by downregulating thymidylate synthase expression. Multiple alternatively spliced transcript variants have been described for this gene but some of their full length sequence is not known. View All» UniProt Summary: FUNCTION: SwissProt: O00213 # May modulate the internalization of beta-amyloid precursor protein.SIZE: 710 amino acids; 77244 Da SUBUNIT: Binds to the intracellular domain of the beta-amyloid precursor protein. Interacts, through the WW domain, with proline- rich regions of APBB1IP and ENAH (By similarity).TISSUE SPECIFICITY: Highly expressed in brain.SIMILARITY: SwissProt: O00213 ## Contains 2 PID domains. & Contains 1 WW domain. View All» Brand Family: Upstate View All» Product Name: Anti-FE65 Antibody, clone 3H6 | 05-758 View All» Concentration: Variable View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 μL View All» Format: Ascites View All» Host: Mouse View All»
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