货号：05-848

品牌：Merck Millipore

规格：

目录价：￥4774.00

市场价格：￥4057.90

会员价格：￥3819.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Neurofilament Antibody, heavy chain, KEP segment, clone 3G3 | 05-848 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Neurofilament heavy chain View All» Molecular Weight: 200kDa View All» Immunogen: Trp-E fusion protein corresponding to residues 846-1072 of rat neurofilament heavy chain. View All» Clone: 3G3 View All» Isotype: IgG View All» Species Reactivity:

• Mouse

• Rat
  View All» Quality Assurance: Routinely evaluated by immunoblot on rat brain microsomal preparation (12-144). View All» Purification Method: Ascites View All» Presentation: Ascites in 0.05% sodium azide and 30% glycerol View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: P12036 View All» Entrez Gene Number: NM_021076 View All» Gene Symbol:
  • NEFH

  • NF-H

  • KIAA0845

  • NFH
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry

    • Immunohistochemistry
      View All» UniProt Summary: FUNCTION: SwissProt: P12036 # Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins.SIZE: 1026 amino acids; 112480 Da PTM: There are a number of repeats of the tripeptide K-S-P, NFH is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFH results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber. & Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H), the levels of phosphorylation being altered developmentally and coincident with a change in the neurofilament function.DISEASE: SwissProt: P12036 # Defects in NEFH are a cause of susceptibility to amyotrophic lateral sclerosis (ALS) [MIM:105400]. ALS is a neurodegenerative disorder affecting upper and lower motor neurons, and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology is likely to be multifactorial, involving both genetic and environmental factors.SIMILARITY: SwissProt: P12036 ## Belongs to the intermediate filament family. View All» Brand Family: Upstate View All» Product Name: Anti-Neurofilament Antibody, heavy chain, KEP segment, clone 3G3 | 05-848 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Ascites View All» Host: Mouse View All»
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