货号：05-879

品牌：Merck Millipore

规格：100Ug

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Prothrombin Antibody, clone GMA-095 | 05-879 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Prothrombin View All» Molecular Weight: Mr 72kDa View All» Immunogen: Purified human Prothrombin View All» Isotype: IgG1 View All» Species Reactivity: Human View All» Quality Assurance: routinely evaluated by immunoblot on human prothrombin View All» Purification Method: DEAE purified View All» Storage Conditions: stable 2 years at -20°C from date of shipment View All» UniProt Number: P00734 View All» Entrez Gene Number: NM_000506 View All» Gene Symbol:

• F2

• prothrombin

• PT
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • ELISA

  • Western Blotting
    View All» Entrez Gene Summary: Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia. View All» UniProt Summary: FUNCTION: SwissProt: P00734 # Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C.SIZE: 622 amino acids; 70037 Da SUBCELLULAR LOCATION: Secreted, extracellular space.TISSUE SPECIFICITY: Expressed by the liver and secreted in plasma.PTM: The gamma-carboxyglutamyl residues, which bind calcium ions, result from the carboxylation of glutamyl residues by a microsomal enzyme, the vitamin K-dependent carboxylase. The modified residues are necessary for the calcium-dependent interaction with a negatively charged phospholipid surface, which is essential for the conversion of prothrombin to thrombin.DISEASE: SwissProt: P00734 # Defects in F2 are the cause of various forms of dysprothrombinemia [MIM:176930]. & Genetic variations in F2 may be a cause of susceptibility to ischemic stroke [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.SIMILARITY: SwissProt: P00734 ## Belongs to the peptidase S1 family. & Contains 1 Gla (gamma-carboxy-glutamate) domain. & Contains 2 kringle domains. & Contains 1 peptidase S1 domain.MISCELLANEOUS: Prothrombin is activated on the surface of a phospholipid membrane that binds the amino end of prothrombin and factors Va and Xa in Ca-dependent interactions; factor Xa removes the activation peptide and cleaves the remaining part into light and heavy chains. The activation process starts slowly because factor V itself has to be activated by the initial, small amounts of thrombin. & It is not known whether 1 or 2 smaller activation peptides, with additional cleavage after Arg-314, are released in natural blood clotting. & Thrombin can itself cleave the N-terminal fragment (fragment 1) of the prothrombin, prior to its activation by factor Xa. & The cleavage after Arg-198, observed in vitro, does not occur in plasma. View All» Brand Family: Upstate View All» Product Name: Anti-Prothrombin Antibody, clone GMA-095 | 05-879 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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