货号：05-890

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Nore1A Antibody, clone 10F10 | 05-890 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Nore1A View All» Molecular Weight: Mr 45 & 47kDa View All» Immunogen: 6His-tagged fusion protein corresponding to residues 119-414 of human Nore1A View All» Isotype: IgG1κ View All» Species Reactivity: Human View All» Application Notes: Not recommended for Immunoprecipitation View All» Quality Assurance: routinely evaluated by immunoblot on RIPA lysates from HaCaT and HeLa cells View All» Purification Method: Protein G purfied View All» Storage Conditions: stable 2 years at -20°C from date of shipment View All» UniProt Number: Q8WWW0 View All» Entrez Gene Number: NM_182663 View All» Gene Symbol:

• RASSF5

• NORE1B

• NORE1A

• RAPL

• MGC10823

• Maxp1

• MGC17344

• NORE1

• RASSF3
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene. View All» UniProt Summary: FUNCTION: SwissProt: Q8WWW0 # Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4 complex may mediate HRAS1 and KRAS induced apoptosis.SIZE: 418 amino acids; 47090 Da SUBUNIT: Interacts directly with activated HRAS1; a RASSF5-STK4 complex probably associates with activated HRAS1. Interacts with KRAS. Probably interacts with Ras-like GTPases RRAS, RRAS2, MRAS, RAP1B, RAP2A and RALA. Can self-associate. Interacts with RSSF1 isoform A. The RSSF1 isoform A-RSSF5 heterodimer probably mediates the association of RSSF1 with HRAS1 (By similarity). Isoform 2 interacts with activated RAP1A and ITGAL/LFA-1. Binds STK4/MST1, inhibiting STK4 autoactivation.SUBCELLULAR LOCATION: Cytoplasm. Note=Isoform 2 is mainly located in the perinuclear region of unstimulated primary T cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A.TISSUE SPECIFICITY: Widely expressed. Frequently down-regulated in lung tumor cell lines and primary lung tumors.SIMILARITY: SwissProt: Q8WWW0 ## Contains 1 phorbol-ester/DAG-type zinc finger. & Contains 1 Ras-associating domain. & Contains 1 SARAH domain. View All» Brand Family: Upstate View All» Product Name: Anti-Nore1A Antibody, clone 10F10 | 05-890 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Mouse View All»
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