货号：05-897

品牌：Merck Millipore

规格：

目录价：￥4739.00

市场价格：￥4028.15

会员价格：￥3791.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-HDAC9 Antibody, clone LH/JC2 | 05-897 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: HDAC9 View All» Molecular Weight: 160kDa View All» Immunogen: synthetic peptide corresponding to amino acids 1046-1060 of human HDAC9 isoform 5 View All» Isotype: IgM View All» Species Reactivity: Human View All» Quality Assurance: Routinely evaluated by immunoblot with RIPA lysates from HeLa cells. View All» Purification Method: Protein G purfied View All» Storage Conditions: 2 years at -20°C from date of shipment View All» UniProt Number: Q9UKV0 View All» Entrez Gene Number:

• NM_014707.1

• NM_058176.2

• NM_058177.2

• NM_178423.1

• NM_178425.2
  View All» Gene Symbol:
  • HDAC9

  • HDAC9FL

  • MITR

  • HD9

  • HDRP

  • HDAC9B

  • KIAA0744

  • DKFZp779K1053

  • HDAC

  • HD7B

  • HD7

  • HDAC7B

  • HDAC7
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry
      View All» Entrez Gene Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined. View All» UniProt Summary: FUNCTION: SwissProt: Q9UKV0 # Isoform 3, called MITR/HDRP, lacks active site residues and therefore is catalytically inactive. Represses MEF2-dependent transcription by recruiting HDAC1 and/or HDAC3. Seems to inhibit skeletal myogenesis and to be involved in heart development. Protects neurons from apoptosis, both by inhibiting c-Jun phosphorylation by MAPK10 and by repressing c-Jun transcription via HDAC1 recruitment to c-Jun promoter.SIZE: 1011 amino acids; 111297 Da SUBUNIT: Homodimer. Interacts with CTBP1. The phosphorylated form interacts with 14-3-3 (By similarity). Interacts with HDAC1 and HDAC3, and probably with HDAC4 and HDAC5. Interacts with MEF2, MAPK10, ETV6, NCOR1 and BCL6.SUBCELLULAR LOCATION: Nucleus (By similarity).TISSUE SPECIFICITY: Broadly expressed, with highest levels in brain, heart, muscle and testis. Isoform 3 is present in human bladder carcinoma cells (at protein level).PTM: Phosphorylated on Ser-220 and Ser-450; which promotes 14-3-3- binding, impairs interaction with MEF2, and antagonizes antimyogenic activity. Phosphorylated on Ser-240; which impairs nuclear accumulation (By similarity). Isoform 7 is phosphorylated on Tyr-1010. & Sumoylated.DISEASE: SwissProt: Q9UKV0 # A chromosomal aberration involving HDAC9 is found in a family with Peters anomaly [MIM:604229]. Translocation t(1;7)(q41;p21) with TGFB2 resulting in lack of HDAC9 protein. Peters anomaly consists of a central corneal leukoma, absence of the posterior corneal stroma and Descemet membrane, and a variable degree of iris and lenticular attachments to the central aspect of the posterior cornea.SIMILARITY: SwissProt: Q9UKV0 ## Belongs to the histone deacetylase family. Type 2 subfamily. View All» Brand Family: Upstate View All» Product Name: Anti-HDAC9 Antibody, clone LH/JC2 | 05-897 View All» Antibody Type: Monoclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Rat View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://www.16ao.com/thread-134121.htm
      © Merck Millipore代理05-897 a-HDAC9, clone LH/JC2 100ul，产品报价联系微信jinshanbio