货号：06-004

品牌：Merck Millipore

规格：

目录价：￥3433.00

市场价格：￥2918.05

会员价格：￥2746.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Secreted frizzled-related protein 2 Antibody | 06-004 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Secreted frizzled-related protein 2 corresponding to the C-terminus. View All» Molecular Weight: ~34 kDa observed View All» Epitope: Corresponding to the C-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to human Secreted frizzled-related protein 2 corresponding to the C-terminus. View All» Background Information: Secreted frizzled-related proteins (SFRPs) may play a critical role in carcinogenesis by inhibiting the Wnt/beta-catenin signaling pathway. Secreted frizzled-related protein 2 may be useful to further investigate mammary tumorigenesis as its expression increases with tumor progression in canine mammary gland tumors. Silencing of Secreted frizzled-related protein 2 in mouse embryos has been found to cause severe shortening of the thoracic region. Studies have shown that this protein is the essential stem cell paracrine factor that is thought to regulate myocardial survival and repair damage in the aftermath of an ischemic injury. View All» Species Reactivity:

• Mouse

• Human

• Rat

• Canine

• Primate

• Pig
  View All» Species Reactivity Note: Demonstrated to react with Mouse. Predicted to react with Human, Rat, Canine, Primate, and Porcine based on 100% sequence homology. View All» Control: NIH/3T3/L1 adipocytic lysate View All» Quality Assurance: Evaluated by Western Blot in NIH/3T3/L1 adipocytic lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected Secreted frizzled-related protein 2 on 10 µg of NIH/3T3/L1 adipocytic lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q96HF1 View All» Entrez Gene Number: NP_003004 View All» Gene Symbol:
  • SFRP2

  • SARP-1

  • SARP1

  • sFRP-2

  • FRP-2

  • SDF-5

  • FRP2
    View All» Alternate Names:
    • secreted frizzled-related protein 2

    • secreted apoptosis related protein 1

    • Secreted apoptosis-related protein 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.SUBCELLULAR LOCATION: Secreted (By similarity). TISSUE SPECIFICITY: Expressed in adipose tissue, heart, brain, skeletal muscle, pancreas, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in adipose tissue, small intestine and colon. DOMAIN: The FZ domain is involved in binding with Wnt ligands (By similarity).SEQUENCE SIMILARITIES: Belongs to the secreted frizzled-related protein (sFRP) family.Contains 1 FZ (frizzled) domain.Contains 1 NTR domain. View All» Product Name: Anti-Secreted frizzled-related protein 2 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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