货号：06-009

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-TLR3 Antibody, C-terminus | 06-009 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the N-terminal domain of TLR3. View All» Molecular Weight: ~103 kDa View All» Epitope: C-terminus View All» Immunogen: KLH-conjugated synthetic peptide corres-ponding to the C-terminal region of TLR3. View All» Background Information: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR1 recognizes peptidoglycan and (triacyl) lipoproteins on pathogens, especially gram-positive bacteria. TLR1 is found on the surface of macrophages and neutrophils. View All» Species Reactivity:

• Mouse

• Rat
  View All» Control: Rat thymus, rat spleen or RAW264.7 lysates. View All» Quality Assurance: Evaluated by western blot on RAW264.7 lysate.Western Blot Analysis: 1 μg/mL of this antibody was used to detect TLR3 in RAW264.7 lysate. View All» Purification Method: Protein G purfied View All» Presentation: Purified rabbit polyclonal in buffer containing PBS and 0.09% sodium azide. View All» Storage Conditions: Stable for 6 months at 2-8ºC from date of receipt. For long term storage, store at -20ºC.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: O15455 View All» Entrez Gene Number: NP_003256.1 View All» Gene Symbol: CD283 View All» Alternate Names:
  • CD283 antigen

  • toll-like receptor 3
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Participates in the innate immune response to microbial agents. Mediates the innate immune response to ds-RNA, a sign of viral infection. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Ref.5 Ref.6 Ref.7 Ref.8 Ref.9 Ref.10SUBUNIT STRUCTURE: Binds MYD88 via their respective TIR domains By similarity. Interacts with TICAM1. Homodimer formation is triggered by ligand binding and is required for TLR3 signaling. Binding of ds-RNA is required for the interaction with SRC.SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane. Ref.6TISSUE SPECIFICITY: Expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors.PTM: Heavily N-glycosylated, except on that part of the surface of the ectodomain that is involved in ligand binding. Ref.10 Ref.11SIMILARITY: Belongs to the Toll-like receptor family.Contains 22 LRR (leucine-rich) repeats.Contains 1 TIR domain. View All» Product Name: Anti-TLR3, C-terminus View All» Concentration: 0.25 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rabbit View All»
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