货号：06-1029

品牌：Merck Millipore

规格：EA

目录价：￥4164.00

市场价格：￥3539.40

会员价格：￥3331.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-NET55 Antibody | 06-1029 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~31 kDa observed. View All» Epitope: 0 View All» Immunogen: KLH-conjugated linear peptide corresponding to human NET55. View All» Background Information: NET55 is more commonly known as gamma-secretase subunit APH-1 beta (APH-1b). APH-1b is a multipass membrane protein that is related with nicastrin and the heterodimers of the presenilin fragments in human cell lines and rat brain. APH-1b is a part of the gamma-secretase enzyme compound which is responsible for neurodevelopmental signaling pathways. View All» Species Reactivity:

• Rat

• Human

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with human, mouse, and rat. View All» Application Notes: Immunohistochemistry Analysis: 1:500 dilution from a representative lot detected NET55 in mouse brain tissue. View All» Control: Rat liver tissue lysate View All» Quality Assurance: Evaluated by Western Blot in rat liver tissue lysate.Western Blot Analysis: 2 µg/mL of this antibody detected NET55 on 10 µg of rat liver tissue lysate. Note: Western blot performed without Tween. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q8WW43 View All» Entrez Gene Number: NP_112591 View All» Gene Symbol:
  • PSFL

  • APH-1B

  • TAAV688

  • PRO13282

  • APH-1b
    View All» Alternate Names:
    • anterior pharynx defective 1 homolog B (C. elegans)

    • presenilin stabilization factor-like

    • aph-1beta

    • gamma-secretase subunit APH-1B

    • anterior pharynx defective 1B-like

    • Presenilin-stabilization factor-like

    • Aph-1beta
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry
        View All» Entrez Gene Summary: APH1 is a multipass transmembrane protein that interacts with presenilin (see PSEN1; MIM 104311) and nicastrin (APH2; MIM 605254) as a functional component of the gamma-secretase complex. The gamma-secretase complex is required for the intramembrane proteolysis of a number of membrane proteins, including the amyloid-beta precursor protein (APP; MIM 104760) and Notch (MIM 190198).[supplied by OMIM]. View All» UniProt Summary: FUNCTION: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A.SUBUNIT STRUCTURE: Probable component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase activity, although other components may exist (By similarity). Interacts with PSEN1 and PSEN2. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential). TISSUE SPECIFICTY: Weakly or not expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, colon, skeletal muscle, heart and brain. SEQUENCE SIMILARITIES: Belongs to the APH-1 family. View All» Product Name: Anti-NET55 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
        © 金山科研平台是专业的授权总代理区域代理经销平台。
        © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
        © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
        © 本文地址：https://www.16ao.com/thread-134202.htm
        © Merck Millipore代理06-1029 Anti-NET55，产品报价联系微信jinshanbio