货号：06-1030

品牌：Merck Millipore

规格：

目录价：￥4376.00

市场价格：￥3719.60

会员价格：￥3500.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Nicalin Antibody | 06-1030 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: Calculated 63 kDa; Observed ~90 kDa. Difference between calculated and observed molecular weight possibly result of glycolysation at amino acids 241 and 428. View All» Immunogen: KLH-conjugated linear peptide corresponding to human Nicalin. View All» Background Information: Nicalin, also referred to as NET59, is a transmembrane signaling factor for the transforming growth factor-beta (TGFbeta) superfamily. Nicalin is thought to negatively regulate Nodals, which are essential in vertebrate development and various cell fate decisions that are key for the proper development of the embryonic body plan. Nicalin is related to the gamma-secretase, Nicastrin which has been associated to Alzheimer’s disease. Nicalin can also associate with NOMO (Nodal modulator) and plays a role in the assembly and the stability of this interaction. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Pig

• Chimpanzee

• Canine
  View All» Species Reactivity Note: Demonstrated to react with Human and Mouse. Predicted to react with Rat, Porcine, Chimpanzee, and Orangutan based on 100% sequence homology. View All» Application Notes: Western Blot Analysis: 1 µg/mL from a representative lot detected Nicalin on 10 µg of C2C12 cell lysate.Immunocytochemistry Analysis: A representative lot was used by an independent laboratory in IC. (Malik, P., et al. (2010). Cell. Mol. Life Sci. DOI 10.1007/s00018-010-0257-2.) View All» Control: HEK293 cell lysate View All» Quality Assurance: Evaluated by Western Blot in HEK293 cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected Nicalin on 10 µg of HEK293 cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q969V3 View All» Entrez Gene Number: NP_064555 View All» Gene Symbol: NCLN View All» Alternate Names:
  • Nicalin

  • Nicastrin-like protein

  • NET59
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry
      View All» UniProt Summary: FUNCTION: May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning (By similarity).SUBUNIT STRUCTURE: Interacts with NOMO2. Due to the strong similarity between NOMO1, NOMO2 and NOMO3, it probably also interacts with NOMO1 and NOMO3. Participates in a large protein complex, which is not related to the gamma-secretase complex. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein TISSUE SPECIFICTY: Highly expressed in pancreas and skeletal muscle and, at lower levels, in heart. SEQUENCE SIMILARITIES: Belongs to the nicastrin family.SEQUENCE CAUTION: The sequence AAH03076.2 differs from that shown. Reason: Erroneous initiation. The sequence AAH25926.1 differs from that shown. Reason: Erroneous initiation. The sequence CAB66502.1 differs from that shown. Reason: Erroneous initiation. View All» Product Name: Anti-Nicalin View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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