货号：06-1043

品牌：Merck Millipore

规格：

目录价：￥3433.00

市场价格：￥2918.05

会员价格：￥2746.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-MAVS/Cardif Antibody, N-terminus | 06-1043 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes MAVS at the N-terminus. Splicing variants observed at ~33, 55, 60, and 65 kDa. (Lad, S., et al. (2008). Molecular Immunology 45:2277–2287.) View All» Molecular Weight: ~35, 55 and 65 kDa observed. Splicing variants were observed at ~35, 55 and 65 kDa. The additional band at ~60 kDa is annother potential splicing variant. (Lad, S., et al. (2008). Molecular Immunology. 45:2277–2287.) View All» Epitope: N-terminus View All» Immunogen: GST-tagged recombinant protein corresponding to the N-terminus of Mitochondrial antiviral-signaling protein. View All» Background Information: Mitochondrial antiviral-signaling protein (MAVS) is thought to activate NF-KappaB and IRF 3, which increase antiviral immunity. This result seems to point to mitochondrial involvement in innate immunity, specifically during viral infection. MAVS also seems to be involved in the activation of interferons, but only during viral contamination. It has been shown that MAVS works in conjunction with retinoic acid inducible gene I (RIG-I) to identify and remove replicating viral genomes. MAVS has been shown to be cleaved during apoptosis and viral infection, which could mean that this is an essential step of infection. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. Other homologies: Chimpanzee (99% sequence homology). Rhesus macaque sequence homology). Rat (46% sequence homology). Mouse (44% sequence homology). View All» Application Notes: Immunoprecipitation Analysis: A previous lot was used by an independent laboratory in IP. (Lad, S., et al. (2008). Molecular Immunology. 45:2277–2287.) View All» Control: A549 cell lysate View All» Quality Assurance: Evaluated by Western Blot in A549 cell lysate.Western Blot Analysis: 1:1,000 dilution from a previous lot detected MAVS/Cardif on 10 µg of A549 cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q7Z434 View All» Entrez Gene Number: NP_065797 View All» Gene Symbol:

• MAVS

• VISA

• IPS-1

• IPS1
  View All» Alternate Names:
  • mitochondrial antiviral signaling protein

  • IFN-B promoter stimulator 1

  • CARD adaptor inducing IFN-beta

  • virus-induced signaling adapter variant 1b

  • Cardif

  • Interferon beta promoter stimulator protein 1

  • CARD adapter inducing interferon-beta

  • Putative NF-kappa-B-activating protein 031N

  • interferon-beta promoter stimulator protein 1

  • Virus-induced-signaling adapter

  • mitochondrial antiviral-signaling protein

  • CARD adapter inducing interferon beta

  • virus-induced signaling adaptor variant 1a

  • CARDIF

  • mitochondrial anti-viral signaling protein
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunoprecipitation
      View All» Entrez Gene Summary: Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 (MIM 603029) or by the cytoplasmic RNA helicases MDA5 (MIM 606951) and RIGI (ROBO3; MIM 608630). These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK; MIM 600664) and IKKB (IKBKB; MIM 603258), which activate NFKB (see MIM 164011), or TBK1 (MIM 604834) and IKKE (IKBKE; MIM 605048), which activate IRF3 (MIM 603734). Activated IRF3 and NFKB induce transcription of IFNB (IFNB1; MIM 147640). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1; MIM 607601). For RIGI, the intermediary protein is mitochondria-bound IPS1 (Sen and Sarkar, 2005 [PubMed 16239922]).[supplied by OMIM]. View All» UniProt Summary: FUNCTION: Required for innate immune defense against viruses. Acts downstream of DDX58 and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis. SUBUNIT STRUCTURE: Interacts with DDX58, IFIH1, TRAF2 and TRAF6. May interact with IRF3, FADD, RIPK1, IKBKE, CHUK and IKBKB. Does not interact with TBK1. Interacts with and is cleaved by HCV and hepatitis GB virus B NS3/4A proteases. Interacts with and is cleaved by HHAV protein 3ABC. Interacts with NLRX1. Interaction with NLRX1 requires the CARD domain. Interacts with PSMA7. Interacts with TRAFD1 By similarity. Interacts (via C-terminus) with PCBP2 in a complex containing MAVS, PCBP2 and ITCH. Interacts with CYLD. SUBCELLULAR LOCATION: Mitochondrion outer membrane TISSUE SPECIFICTY: Present in T-cells, monocytes, epithelial cells and hepatocytes (at protein level). Ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood leukocytes. DOMAIN: Both CARD and transmembrane domains are essential for antiviral function. The CARD domain is responsible for interaction with DDX58 and IFIH1.PTM: Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination catalyzed by ITCH; ITCH-dependent polyubiquitination is mediated by the interaction with PCBP2 and leads to MAVS proteosomal degradation. MISCELLANEOUS: Cleavage by HCV protease complex leads to inactivation.SEQUENCE SIMILARITIES: Contains 1 CARD domain.SEQUENCE CAUTION: The sequence BAA86585.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB14684.1 differs from that shown. Reason: Frameshift at position 333. View All» Product Name: Anti-MAVS/Cardif, N-terminus View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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