货号：06-1047

品牌：Merck Millipore

规格：

目录价：￥3908.00

市场价格：￥3321.80

会员价格：￥3126.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-IRF4 Antibody, N-terminus | 06-1047 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the N-terminal region of IRF4 at and around amino acids 177-194. View All» Molecular Weight: ~52 kDa View All» Epitope: N-Terminus View All» Immunogen: KLH conjugated linear peptide corresponding to the N-terminal region of IRF4. View All» Background Information: Interferon regulatory factor 4, also known as IRF4, belongs to the IRF family. IRF4 encodes a 450 amino acid polypeptide with a predicted molecular weight of 51.6 kDa (Grossman 1996). The IRF4 gene is expressed in the spleen, lymphocytes and melanocytes, and is induced in to T cells after cross linking with the T cell receptor. IRF4 is a transcriptional activator that binds to the interferon stimulated response element (ISRE) of the MHC class I promoter. IRF4 is essential for mature T and B lymphocyte function. IRF4 interacts with MYD88 to prevent the interaction of IRF5, resulting in negative regulation of Toll Like Receptor (TLR) signaling. High levels of IRF4 have been associated with Epstein Barr Virus (EBV) and may be critical to EBV transformation. Further oncogenic potential has been associated with the involvement of IRF4 with hair color and pigmentation of the skin, which may cause multiple myeloma. View All» Species Reactivity:

• Human

• Mouse

• Horse

• Rat
  View All» Species Reactivity Note: Tested to react with human and mouse. Predicted to react with rat and horse based on sequence homology. View All» Application Notes: Immunocytochemistry: 1:500 dilution of a previous lot of this antibody was used on immunocytochemistry in PC3 cells. View All» Control: Mouse brain lysate. View All» Quality Assurance: Evaluated by western blot on mouse brain lysate.Western Blot Analysis: 0.5 μg/mL of this antibody detected IRF4 in 10 μg of mouse brain lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8ºC from date of receipt. View All» UniProt Number: Q15306 View All» Entrez Gene Number: NM_002460 View All» Gene Symbol:
  • IRF-4

  • LSIRF

  • MUM1

  • NF-EM5
    View All» Alternate Names:
    • Lymphocyte-specific interferon regulatory factor

    • Multiple myeloma oncogene

    • interferon regulatory factor 4
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry
        View All» UniProt Summary: Function: Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells.Subunit structure: Interacts with SPIB and DEF6. Ref.5 Ref.6Subcellular location: Nucleus. Tissue specificity: Lymphoid cells.Induction: Not induced by interferons.Involvement in disease: A chromosomal aberration involving IRF4 may be a cause of multiple myeloma [MIM:254500]. Translocation t(6;14)(p25;q32) with the IgH locus.Sequence similarities: Belongs to the IRF family.Contains 1 tryptophan pentad repeat DNA-binding domain. View All» Product Name: Anti-IRF4, N-terminus View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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