货号：06-1048

品牌：Merck Millipore

规格：EA

目录价：￥3108.00

市场价格：￥2641.80

会员价格：￥2486.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PACT Antibody, domain 2 | 06-1048 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes domain 2 of PACT. View All» Molecular Weight: ~34 kDa. View All» Epitope: Domain 2 View All» Immunogen: KLH-conjugated synthetic linear peptide corresponding to domain 2 of PACT. View All» Background Information: PACT is also known as a protein activator of the interferon-induced protein kinase, PKR. PACT is a heterodimer with 3 double stranded RNA binding domains (DRBM) and acts as an antiviral mediator, growth regulator and signal transducer stimulated by stress. PACT activates EIF2AK2 in the absence of double stranded RNA binding via the DRBM domains. Suppression of PACT occurs in the presence of growth factor and is thought to be involved in dystonia type 16, which leads to axial muscle movement, Parkinsonian features and sardonic smile. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Mouse. Predicted to cross-react with human (Rowe, T.M., et al. 2006) and rat based on sequence homology. View All» Control: Mouse brain lysate View All» Quality Assurance: Evaluated by western blot on mouse brain lysate.Western Blot Analysis: A 1:1000 dilution of this antibody detected PACT on wild type mouse brain lysates. View All» Purification Method: Unpurified View All» Presentation: Unpurified rabbit polyclonal serum. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt.Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: O75569 View All» Entrez Gene Number: NP_001132989.1 View All» Gene Symbol:
  • RAX

  • PACT

  • HSD14

  • DYT16
    View All» Alternate Names:
    • PKR-associated protein X

    • PKR-associating protein X

    • Protein activator of the interferon-induced protein kinase

    • Protein kinase, interferon-inducible double strandedRNA-dependent activator

    • protein kinase, interferon-inducible double stranded RNAdependent activator
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Appears to have a pro-apoptotic function that may be suppressed in the presence of growth factor By similarity. Activates EIF2AK2 in absence of double stranded RNA (dsRNA).SUBUNIT: Heterodimer. Interacts with EIF2AK2 through its DRBM domains. Also able to interact with dsRNA. Ref.1PTM: Phosphorylated on serine By similarity.DISEASE: Defects in PRKRA are the cause of dystonia type 16 (DYT16) [MIM:612067]. Affected individuals have progressive, generalised, early-onset dystonia with axial muscle involvement, oromandibular (sardonic smile), laryngeal dystonia and, in some cases, parkinsonian features. Ref.14 Ref.15SIMILARITY: Contains 3 DRBM (double-stranded RNA-binding) domains. View All» Product Name: Anti-PACT, domain 2 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μL View All» Format: Serum View All» Host: Rabbit View All»
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