货号：06-1052

品牌：Merck Millipore

规格：EA

目录价：￥3228.00

市场价格：￥2743.80

会员价格：￥2582.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Emerin Antibody | 06-1052 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Emerin at and around the N-terminus. View All» Molecular Weight: ~35 kDa View All» Epitope: N-terminus View All» Immunogen: Recombinant protein corresponding to residues surrounding the N-terminus region of Emerin. View All» Background Information: Emerin is a LEM domain-containing integral membrane protein of the nuclear membrane in vertebrates. Emerin is known to interact with nuclear lamins, barrier-to-autointegration factor (BAF), nesprin-1 alpha, and a transcription repressor. Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Mutations to emerin result in Dreifuss-Emery muscular dystrophy, an X-linked inherited degenerative myopathy. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Control: A431 cell lysate View All» Quality Assurance: Evaluated by Western Blot in A431 cell lysate.Western Blot Analysis: A 1:1,000 dilution of this antibody detected Emerin in 10 µg of A431 cell lysate. View All» Purification Method: Unpurified View All» Presentation: Rabbit polyclonal serum with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: P50402 View All» Entrez Gene Number: NP_000108.1 View All» Gene Symbol:

• EDMD

• LEMD5

• OTTHUMP00000031938

• OTTHUMP00000061687

• STA

• emerin
  View All» Alternate Names:
  • Emery-Dreifuss muscular dystrophy

  • LEM domain containing 5
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene. View All» UniProt Summary: SUBUNIT STRUCTURE: Interacts with lamins A and C, BANF1, GMCL, BCLAF1 and YTHDC1/YT521. Interacts with TMEM43; the interaction retains emerin in the nuclear inner membrane By similarity.SUBCELLULAR LOCATION: Nucleus inner membrane; Single-pass membrane protein; Nucleoplasmic side. Note: Colocalized with BANF1 at the central region of the assembling nuclear rim, near spindle-attachment sites. TISSUE SPECIFICITY: Skeletal muscle, heart, colon, testis, ovary and pancreas.PTM: Found in four different phosphorylated forms, three of which appear to be associated with the cell cycle. INVOLVEMENT IN DISEASE: Defects in EMD are a cause of X-linked Emery-Dreifuss muscular dystrophy (X-EDMD) [MIM:310300]. X-EDMD is an X-linked disorder characterized by early contractures, muscle wasting and weakness and cardiomyopathy. MISCELLANEOUS: Binding to BCLAF1 is specifically and selectively disrupted by the disease-associated Phe-54 missense mutation.SEQUENCE SIMILARITIES: Contains 1 LEM domain. View All» Product Name: Anti-Emerin View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Unpurified View All» Host: Rabbit View All»
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