货号：06-1067

品牌：Merck Millipore

规格：

目录价：￥3615.00

市场价格：￥3072.75

会员价格：￥2892.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Interleukin 10 Receptor Alpha (IL-10RA) Antibody | 06-1067 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the cytoplasmic domain of IL-10RA. View All» Molecular Weight: ~63 kDa View All» Epitope: Cytoplasmic Domain View All» Immunogen: KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human IL-10RA. View All» Background Information: Interleukin 10 receptor, alpha subunit (IL-10RA or CDW210A) is a subunit for the interleukin-10 receptor and a single-pass type I membrane protein. The IL-10 receptor complex contains two subunits, the ligand binding IL10RA and the IL10RB. IL-10RA has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibit the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. IL-10RA is found in spleen, thymus, and PBMCs and is highly expressed in monocytes, B-cells, large granular lymphocytes, and T-cells. IL-10RA is weakly expressed in pancreas, skeletal muscle, brain, heart, and kidney tissues, and intermediately expressed in placenta, lung, and liver tissue. View All» Species Reactivity:

• Human

• Mouse

• Chimpanzee
  View All» Species Reactivity Note: Demonstrated to react with human and mouse. Predicted to react with chimpanzee based on 100% sequence homology. View All» Application Notes: Flow Cytometry Analysis: 5 µg of antibody from a previous lot detected IL-10RA in human PBMC's.Immunohistochemistry Analysis: A 1:100 dilution from a previous lot detected IL-10RA in mouse spleen tissue. View All» Control: Human thymus lysate View All» Quality Assurance: Evaluated by Western Blot in human thymus lysate.Western Blot Analysis: 0.1 µg/mL of this antibody detected IL-10RA on 10 µg of human thymus lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in PBS with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q13651 View All» Entrez Gene Number: NP_001549 View All» Gene Symbol:
  • IL10RA

  • CDW210A

  • HIL-10R

  • IL-10R-A

  • IL-10R1

  • IL10R
    View All» Alternate Names:
    • CDw210a antigen

    • interleukin 10 receptor, alpha

    • interleukin-10 receptor alpha chain
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry (Paraffin)

      • Flow Cytometry
        View All» Entrez Gene Summary: The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Receptor for IL10; binds IL10 with a high affinity.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICTY: Spleen, thymus, and PBMC. Weak expression in pancreas, skeletal muscle, brain, heart, and kidney. Placenta, lung, and liver showed intermediate levels. Monocytes, B-cells, large granular lymphocytes, and T-cells express high levels.SEQUENCE SIMLARITIES: Belongs to the type II cytokine receptor family. View All» Product Name: Anti-Interleukin 10 Receptor Alpha (IL-10RA) View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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