货号：06-1074

品牌：Merck Millipore

规格：100Ug

目录价：￥3574.00

市场价格：￥3037.90

会员价格：￥2859.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Interleukin 21 (IL-21) Antibody | 06-1074 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the C-terminus of IL-21. View All» Molecular Weight: A molecular weight of 18 kDa was observed; however, UniProtKB/Swiss-Prot entry Q9HBE4 (IL21_HUMAN) describes 2 isoforms produced by alternative splicing: isoform 1 at 18 kDa, isoform 2 at 17 kDa. View All» Epitope: C-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to the C-terminus of human IL-21. View All» Background Information: Interleukin 21 (IL-21) is a cytokine that has immunoregulatory activity on cells of the immune system, including natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells. IL-21 induces cell division/proliferation in its target cells and is expressed in activated human CD4+ T cells. IL-21 may promote the transition between innate and adaptive immunity and may play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. IL-21 expression is up-regulated in Th2 and Th17 subsets of T helper cells, as well as follicular T cells. Furthermore IL-21 is expressed in NK T cells regulating the function of these cells. IL-21 is also produced by Hodgkin's lymphoma (HL) cancer cells and may explain a great deal of the behavior of classical Hodgkin's lymphoma including clusters of other immune cells gathered around HL cells in cultures. View All» Species Reactivity:

• Human

• Mouse

• Monkey

• Chimpanzee
  View All» Species Reactivity Note: Demonstrated to react with human and mouse. Predicted to react with monkey and chimpanzee based on 100% sequence homology. Cow, canine, equine, and porcine (93% sequence homology). Rat (86% sequence homology). View All» Application Notes: Flow Cytometry Analysis: 5 µg from a previous lot detected IL-21 in human PBMC's.Immunohistochemistry Analysis: A 1:100 dilution from a previous lot detected IL-21 in mouse spleen tissue. View All» Control: K562 cell lysate View All» Quality Assurance: Evaluated by Western Blot in K562 cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected IL-21 on 10 µg of K562 cell lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal in PBS with 0.06% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9HBE4 View All» Entrez Gene Number: NP_068575 View All» Gene Symbol:
  • IL21R

  • IL-21R

  • NILR
    View All» Alternate Names:
    • Za11

    • IL-21

    • IL21

    • Interleukin-21
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Flow Cytometry

      • Immunohistochemistry (Paraffin)

      • Western Blotting
        View All» UniProt Summary: FUNCTION: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG1 and IgG3 in B-cells By similarity. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. SUBCELLULAR LOCATION: Secreted TISSUE SPECIFICTY: Expressed in activated CD4-positive T-cells but not in CD8-positive T-cells, B-cells, or monocytes. SEQUENCE SIMILARITIES: Belongs to the IL-15/IL-21 family. View All» Product Name: Anti-Interleukin 21 (IL-21) View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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