货号：06-1087

品牌：Merck Millipore

规格：

目录价：￥3574.00

市场价格：￥3037.90

会员价格：￥2859.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-DKK2 Antibody | 06-1087 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~32 kDa observed View All» Immunogen: KLH-conjugated linear peptide corresponding to human DKK2. View All» Background Information: Dickkopf-related protein 2 (DKK2) is a member of the dickkopf family and are a necessary component of vertebrate development through its interactions with the Wnt signaling pathway. DKK2 has the ability to act as an agonist or antagonist of Wnt/beta-catenin signaling which depends upon the cellular context and presence of the co-factor kremen 2. DKK2 is expressed in the brain, skeletal muscle, lung, and heart. Mutations in DKK2 are associated with bone disease. View All» Species Reactivity:

• Human

• Mouse

• Rat

• Canine

• Horse
  View All» Species Reactivity Note: Demonstrated to react with human and mouse. Predicted to react with rat, canine, and equine based on 100% sequence homology. View All» Application Notes: Immunohistochemistry Analysis: 1:300 dilution from a previous lot detected DKK2 in normal human myocardial tissue. View All» Control: Human brain tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human brain tissue lysate.Western Blot Analysis: 0.25 µg/mL of this antibody detected DKK2 on 10 µg of human brain tissue lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9UBU2 View All» Entrez Gene Number: NP_055236 View All» Gene Symbol:
  • hDkk-2

  • dickkopf 2

  • DKK-2

  • Dkk-2
    View All» Alternate Names:
    • dickkopf homolog 2 (Xenopus laevis)

    • dickkopf-related protein 2

    • dickkopf (Xenopus laevis) homolog 2

    • dickkopf related protein-2

    • Dickkopf-2

    • dickkopf-2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry
        View All» Entrez Gene Summary: This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer's disease (By similarity).SUBUNIT STRUCTURE: Interacts with LRP5 and LRP6 (By similarity).SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICTY: Expressed in heart, brain, skeletal muscle and lung.DOMAIN: The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6 (By similarity).PTM: May be proteolytically processed by a furin-like protease.SEQUENCE SIMILARITIES: Belongs to the dickkopf family. View All» Product Name: Anti-DKK2 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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