货号：06-1089

品牌：Merck Millipore

规格：

目录价：￥3346.00

市场价格：￥2844.10

会员价格：￥2676.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-IL-12R-beta-1 Antibody | 06-1089 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes IL-12R-beta-1 at the cytoplasmic domain. View All» Molecular Weight: ~110 kDa observed. (Stern, A., et al. (1996). Life Sciences. 58(8):639-654.) View All» Epitope: Cytoplasmic domain View All» Immunogen: KLH-conjugated linear peptide corresponding to human IL-12R-beta-1 at the cytoplasmic domain. View All» Background Information: Interleukin 12 receptor beta 1 (IL-12R-beta-1) is a low affinity receptor for IL-12. IL-12R-beta-1 is thought to combine with IL-12R-beta-2 to form a high affinity receptor for IL-12. It can also associate with IL-23R to form the receptor for Interleukin 23. IL-12R-beta-1, in the IL-23R form, may be involved in IL23 signal transduction through the launch of the Jak-Stat signaling cascade and is also thought to play a role in IL-12 transduction. IL-12R-beta-1 deficiency is often linked to severe tuberculosis. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. View All» Application Notes: Immunohistochemistry Analysis: 1:300 dilution from a previous lot detected IL-12R-beta-1 in normal human spleen tissue. View All» Control: Jurkat cell lysate View All» Quality Assurance: Evaluated by Western Blot in Jurkat cell lysate.Western Blot Analysis: 0.025 µg/mL of this antibody detected IL-12R-beta-1 on 10 µg of Jurkat cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P42701 View All» Entrez Gene Number: NP_005526 View All» Gene Symbol:

• IL-12RB1

• CD212

• IL-12R-BETA1

• IL12RB

• IL12RB1

• IL12R
  View All» Alternate Names:
  • interleukin 12 receptor, beta 1

  • interleukin-12 receptor beta-1 chain

  • IL-12R-beta-1

  • IL-12R subunit beta-1

  • interleukin-12 receptor subunit beta-1

  • IL-12 receptor beta component

  • CD212 antigen

  • IL-12 receptor subunit beta-1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunohistochemistry
      View All» Entrez Gene Summary: The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade. Ref.9SUBUNIT STRUCTURE: Dimer or oligomer; disulfide-linked. Interacts with IL12RB2 to form the high affinity IL12 receptor. Heterodimer with IL23R; in presence of IL23. The heterodimer forms the IL23 receptor. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. DOMAIN: The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.The box 1 motif is required for JAK interaction and/or activation.INVOLVEMENT IN DISEASE: Defects in IL12RB1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]; also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity, whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. SEQUENCE SIMLARITIES: Belongs to the type I cytokine receptor family. Type 2 subfamily.Contains 5 fibronectin type-III domains. View All» Product Name: Anti-IL-12R-beta-1 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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