货号：06-1103

品牌：Merck Millipore

规格：

目录价：￥3346.00

市场价格：￥2844.10

会员价格：￥2676.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Protein patched homolog 2 Antibody | 06-1103 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Protein patched homolog 2. View All» Molecular Weight: 115 kDa was observed and 130 kDa was calculated View All» Epitope: Extracellular Domain View All» Immunogen: KLH-conjugated linear peptide corresponding to human Protein patched homolog 2 at and around the extracellular domain. View All» Background Information: Protein patched homolog 2 is a 180 - 200 kDa 12 transmembrane member of the Patched family that exists in a signal cascade with Sonic Hedgehog (SHH) and Smoothened (SMO). Protein patched homolog 2 and Smoothened form a membrane complex that serves as a receptor for Sonic Hedgehog (SHH). Protein patched homolog 2 is 1203 amino acids (aa) in length. It has two terminal cytoplasmic domains, one between aa 1 - 57, and a second between aa 1115 - 1203. View All» Species Reactivity:

• Human

• Mouse

• Canine

• Horse
  View All» Species Reactivity Note: Reacts with human. Predicted to react with mouse, canine, and equine based on 100% sequence homology. Chicken and cow (92%). View All» Application Notes: Western Blot (SNAP ID) Analysis: 4 µg/mL from a previous lot detected Protein patched homolog 2 on 10 µg of HeLa cell lysate.Immunohistochemistry Analysis: 1;1,000 dilution from a previous lot detected Protein patched homolog 2 in human placenta tissue. View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected Protein patched homolog 2 on 10 µg of HeLa cell lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9Y6C5 View All» Entrez Gene Number: NP_001159764.1 View All» Gene Symbol:
  • PTCH2

  • PTC2
    View All» Alternate Names:
    • patched (Drosophila) homolog 2

    • patched 2

    • patched homolog 2 (Drosophila)
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry
        View All» Entrez Gene Summary: This gene encodes a transmembrane receptor of the patched gene family. The encoded protein may function as a tumor suppressor in the hedgehog signaling pathway. Alterations in this gene have been associated with nevoid basal cell carcinoma syndrome, basal cell carcinoma, medulloblastoma, and susceptibility to congenital macrostomia. Alternatively spliced transcript variants have been described. View All» UniProt Summary: FUNCTION: May have a role in epidermal development. May act as a receptor for Sonic hedgehog (SHH).SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. INVOLVEMENT IN DISEASE: Defects in PTCH2 are a cause of medulloblastoma (MDB) [MIM:155255]. MDB is a malignant, invasive embryonal tumor of the cerebellum with a preferential manifestation in children. Although the majority of medulloblastomas occur sporadically, some manifest within familial cancer syndromes such as Turcot syndrome and basal cell nevus syndrome (Gorlin syndrome). Defects in PTCH2 are a cause of sporadic basal cell carcinoma (BCC) [MIM:605462]. SEQUENCE SIMILARITIES: Belongs to the patched family.Contains 1 SSD (sterol-sensing) domain. View All» Product Name: Anti-Protein patched homolog 2 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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