货号：06-1110

品牌：Merck Millipore

规格：

目录价：￥3433.00

市场价格：￥2918.05

会员价格：￥2746.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-TRAF6 Antibody | 06-1110 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the MATH (meprin-associated Traf homology) domain of TRAF6. View All» Molecular Weight: ~59 kDa View All» Epitope: MATH (meprin-associated Traf homology) Domain View All» Immunogen: KLH-conjugated linear peptide corresponding to the MATH (meprin-associated Traf homology) domain of human TRAF6. View All» Background Information: TNF receptor-associated factor 6 is a member of the TNF receptor associated factor (TRAF) protein family. TNF receptor-associated factor 6 proteins play an important role as adaptor protein for cell survival, proliferation, differentiation and stress responses. TNF receptor-associated factor 6 has unique binding behavior that result in signaling responses from the interleukin-1 receptor (IL-1R) toll-like receptor. TNF receptor-associated factor 6 mediates signaling indirectly with IL-1R/TLR through IRAK. This leads to activation of NF-κB and MAP kinase signaling pathways though downstream association with the TAB/TAK-1 complex. TNF receptor-associated factor 6 is also involved in the activation of Akt/PKB and serves as a direct E3 ligase which is essential for Akt ubiquitination. View All» Species Reactivity:

• Human

• Horse

• Rhesus Macaque
  View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with equine and rhesus monkey based on 100% sequence homology.Mouse, rat, and ox ( 93% sequence homology). View All» Application Notes: Western Blot (SNAP ID) Analysis: 1 µg/mL from a previous lot detected TRAF6 on 10 µg of Jurkat cell lysate.Immunohistochemistry Analysis: A 1:300 dilution from a previous lot detected TRAF6 in ductal carcinoma tissue.Optimal Staining With Citrate pH 6.0 Epitope Retrieval: Human TMA. View All» Control: Jurkat cell lysate View All» Quality Assurance: Evaluated by Western Blot in Jurkat cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected TRAF6 in 10 µg of Jurkat cell lysate. View All» Purification Method: Protein A purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9Y4K3 View All» Entrez Gene Number: NP_004611 View All» Gene Symbol:
  • TRAF6

  • RNF85
    View All» Alternate Names:
    • Interleukin-1 signal transducer

    • RING finger protein 85

    • TNF receptor-associated factor 6
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry
        View All» Entrez Gene Summary: The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates the signaling not only from the members of the TNF receptor superfamily, but also from the members of the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. Two alternatively spliced transcript variants encoding identical proteins have been reported. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Also involved in the IL-1 signaling pathway via MYD88 and IRAK kinases. Seems to be involved in IL-17 signaling (By similarity). Mediates activation of NF-kappa-B and JNK. May function as an E3 ubiquitin ligase.SIZE: 522 amino acids; 59573 Da SUBUNIT: Homotrimer (Probable). Binds to TNFRSF5/CD40 and TNFRSF11A/RANK. Associates with NGFR, TNFRSF17, IRAK1, IRAK2, IRAK3, IRAK4, RIPK2, MAP3K1, MAP3K5, MAP3K14, CSK, and TRAF- interacting protein TRIP and TRAF and TNF receptor associated protein TTRAP. Interacts with IL17R. Interacts with SQSTM1 bridging NTRK1 and NGFR. Forms a ternary complex with SQSTM1 and PRKCZ (By similarity). Interacts with PELI1, PELI2 and PELI3. Binds UBE2V1. Interacts with MAVS/IPS1. Interacts with TAX1BP1. Interacts with IL1RL1. Interacts with TRAFD1. Interacts with ZNF675.SUBCELLULAR LOCATION: Cytoplasm (Probable).TISSUE SPECIFICITY: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.DOMAIN: The coiled coil domain mediates homo- and hetero- oligomerization. & The MATH/TRAF domain binds to receptor cytoplasmic domains.PTM: Polyubiquitinated (By similarity).SIMILARITY: Contains 1 MATH domain. & Contains 1 RING-type zinc finger. & Contains 2 TRAF-type zinc fingers. View All» Product Name: Anti-TRAF6 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rabbit View All»
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