货号：06-1116

品牌：Merck Millipore

规格：100Ug

目录价：￥4438.00

市场价格：￥3772.30

会员价格：￥3550.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-IL-33R ST2 (IL1RL1) Antibody | 06-1116 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the extracellular domain of IL-33R ST2. View All» Molecular Weight: ~30 kDa observed. UniProtKB/Swiss-Prot Q01638 (ILRL1_HUMAN) entry describes 3 isoforms produced by alternative splicing: Isoform A at 63.358 kDa, Isoform B at 36.993 kDa, Isoform C at 29.951 kDa. The ~37 kDa product is the secreted form. View All» Epitope: Extracellular Domain View All» Immunogen: KLH-conjugated linear peptide corresponding to the extracellular domain of human IL-33R ST2. View All» Background Information: Interleukin-1 receptor-like 1 (IL-33R ST2) is a member of the interleukin-1 receptor family, and is comprised of three Ig-like C2-type domains and a single TIR domain. IL-33R ST2 functions as a receptor for IL-33, and, following phosphorylation with MAPKa/ERK2, MAPK3/ERK1, MAPK8 and/ore MAPK14, serves to recruit IRAK1, IRAk4, MYD88, and TRAF6. It is also thought to have a potential role in the function of helper T-cells. High expression has been reported in colon, kidney, lung, placenta, skeletal muscle, small intestines, and the stomach. Isoform A has been noted to be more prevalent in colon, lung, placenta, testis and stomach, while Isoform B has greater presence in brain, liver and kidney. View All» Species Reactivity:

• Human

• Chimpanzee

• Primate
  View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with chimpanzee and primate based on 100% sequence homology. View All» Application Notes: Immunohistochemistry Analysis: A 1:300 dilution from a previous lot detected IL-33R ST2 in normal human thymus tissue. View All» Control: Human kidney tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human kidney tissue lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected IL-33R ST2 in 10 µg of human kidney tissue lysate. View All» Purification Method: Affinity Purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q01638 View All» Entrez Gene Number: NP_057316 View All» Gene Symbol:
  • T1

  • DER4

  • IL1RL1

  • ST2

  • FIT1

  • ST2L

  • ST2V
    View All» Alternate Names:
    • interleukin 1 receptor-like 1

    • interleukin-1 receptor-like 1

    • growth stimulation-expressed

    • homolog of mouse growth stimulation-expressed

    • interleukin 1 receptor-related protein

    • Protein ST23
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry (Paraffin)
        View All» Entrez Gene Summary: The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function. SUBUNIT STRUCTURE: Interacts with MYD88, IRAK1, IRAK4, and TRAF6. SUBCELLULAR LOCATION: Isoform C: Cell membrane Isoform B: Secreted Ref.10. Cell membrane; Single-pass type I membrane protein TISSUE SPECIFICTY: Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle. Ref.10SEQUENCE SIMILARITIES: Belongs to the interleukin-1 receptor family.Contains 3 Ig-like C2-type (immunoglobulin-like) domains.Contains 1 TIR domain. View All» Product Name: Anti-IL-33R ST2 (IL1RL1) View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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