货号：06-1125

品牌：Merck Millipore

规格：100Ug

目录价：￥4438.00

市场价格：￥3772.30

会员价格：￥3550.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Ipaf (NLRC4) Antibody | 06-1125 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Ipaf at the LRR4 domain. View All» Molecular Weight: ~112 kDa observed. Different lysates may detect different isoforms and splice variants (Isoform 1: 112 kDa, Isoform 2: 41 kDa, Isoform 3: 18 kDa, Isoform 4: 10 kDa). View All» Epitope: LRR4 domain View All» Immunogen: KLH-conjugated linear peptide corresponding to human Ipaf (NLRC4) at the LRR4 domain. View All» Background Information: Ipaf, also known as NLRC4, is a human CED-4 homologue and is thought to be an activator of pro-caspase-1 and might also be associated with the activation of caspase-1 as a response to pro-inflammatory and apoptotic stimulus. It has been shown to be induced by p53 and contributes to p53-dependent apoptosis. Ipaf is thought to play a role in the activation of the innate immune system. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with human and mouse. View All» Application Notes: Western Blot Analysis: 1 µg/mL of this antibody detected Ipaf in 10 µg of jurkat cell lysate. For this particular lysate, the antibody detected isoform 2 splice variant.Immunocytochemistry Analysis: A 1:500 dilution from a previous lot detected Ipaf in NIH/3T3 cells. View All» Control: Human lung tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human lung tissue lysate.Western Blot Analysis: 1 µg/mL of this antibody detected Ipaf in 10 µg of human lung tissue lysate. View All» Purification Method: Affinity Purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9NPP4 View All» Entrez Gene Number: NP_067032 View All» Gene Symbol:
  • IPAF

  • CLAN

  • CARD12

  • CLAN1

  • ipaf

  • CLR2.1

  • CLAND

  • CLANA

  • CLANB

  • CLANC

  • Ipaf
    View All» Alternate Names:
    • NLR family, CARD domain containing 4

    • NOD-like receptor C4

    • caspase recruitment domain family, member 12

    • ICE-protease activating factor

    • nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 4

    • NLR family CARD domain-containing protein 4

    • Caspase recruitment domain-containing protein 12

    • Ice protease-activating factor

    • Clan protein

    • CARD, LRR, and NACHT-containing protein
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunocytochemistry

      • Western Blotting
        View All» Entrez Gene Summary: Summary: In C. elegans, Ced4 binds and activates Ced3, an apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include APAF1 (MIM 602233), NOD1/CARD4 (MIM 605980), and NOD2/CARD15 (MIM 605956). These proteins have at least 1 N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a C-terminal regulatory domain, found only in mammals, that contains either WD40 repeats or leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce apoptosis.[supplied by OMIM]. View All» UniProt Summary: FUNCTION: Plays a role in the promotion of apoptosis.SUBUNIT STRUCTURE: Self-associates and binds to ASC, pro-caspase-1, NOD2, BCL10 and NALP1 (NAC) by CARD-CARD interaction.SUBCELLULAR LOCATION: Cytoplasm. Note: Cytoplasmic filaments.TISSUE SPECIFICITY: Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen. Isoform 1 is highly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver. Isoform 4 is only detected in brain.SEQUENCE SIMILARITIES: Contains 1 CARD domain.Contains 14 LRR (leucine-rich) repeats.Contains 1 NACHT domain. View All» Product Name: Anti-Ipaf (NLRC4) View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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